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Effect of wild Korean ginseng (Panax ginseng) extract on blood glucose and serum lipid contents in rats with multiple low-dose streptozotocin-induced diabetes

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Abstract

Anti-diabetic effects of wild Korean ginseng extracts on multiple low-dose streptozotocin (STZ)-induced diabetic rats were investigated. Rats were administered extracts at rates of 100, 200, and 300 mg/kg of body weight for 8 weeks. Body weight was significantly (p<0.05) lower in ginseng untreated diabetic rats than in ginseng treated rats in spite of significantly (p<0.05) higher food and water intake than for ginseng treated rats. Blood glucose levels were significantly (p<0.05) higher but plasma insulin levels were significantly (p<0.05) lower in 200 and 300 mg/kg of body weight ginseng treated diabetic rats than in rats treated with 100 mg of ginseng and in untreated control rats. The plasma aspartate aminotransaminase level was not significantly (p>0.05) affected; however alanine aminotransaminase and alkaline phosphatase levels were reduced significantly (p<0.05) in higher ginseng dosage rat groups. Anti-diabetic effects were elicited by administration of wild Korean ginseng extracts in multiple low-dose STZ-induced diabetic rats.

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Authors and Affiliations

  1. School of Food Science and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea

    Hye-Kyung Moon & Shin-Kyo Chung

  2. College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Korea

    Kil-Soo Kim

  3. Department of Food and Food-Service Industry, Kyungpook National University, Sangju, Gyeongbuk, 742-711, Korea

    Jong-Kuk Kim

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  1. Hye-Kyung Moon
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  2. Kil-Soo Kim
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  4. Jong-Kuk Kim
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Correspondence to Jong-Kuk Kim.

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Moon, HK., Kim, KS., Chung, SK. et al. Effect of wild Korean ginseng (Panax ginseng) extract on blood glucose and serum lipid contents in rats with multiple low-dose streptozotocin-induced diabetes. Food Sci Biotechnol 24, 1505–1511 (2015). https://doi.org/10.1007/s10068-015-0194-9

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  • DOI: https://doi.org/10.1007/s10068-015-0194-9

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