Skip to main content
SpringerLink
Log in

Anti-atherogenic properties of emulsified perilla oil (EPO) in apo E KO mice and plasma lipid lowering effects of rice porridge containing EPO in healthy young adults

  • Research Article
  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

The objective of this study was to develop a rice porridge containing perilla oil rich in α-linolenic acid which demonstrated anti-atherogenic effect in the previous study. Lipid lowering effect of emulsified perilla oil (EPO) was examined in apo E KO mice (n=18) and that for rice porridge containing EPO (RPEPO) was investigated in the pilot scale human study (n=20). Inhibitory effects of EPO on the plasma lipid levels and fatty streak lesion size in apo E KO mice were similar to those observed in mice fed perilla oil (PO), suggesting that EPO is applicable form of PO in manufacturing rice porridge product with PO’s health benefit properties. In human study with young adults aged between 20–35 years old, changes in plasma triglyceride concentration of subjects consumed RPEPO for 30 days as a breakfast was significantly lowered than those for subjects consumed rice porridge (p<0.05), of which calorie levels were the same (333 kcal/meal).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Shin HS, Kim SW. Lipid composition of perilla seed. J. Am. Oil Chem. Soc. 71: 619–622 (1994)

    Article  CAS  Google Scholar 

  2. Ihara M, Umekawa H, Takahashi T, Furuichi Y. Comparative effects of short- and long-term feeding of safflower oil and perilla oil on lipid metabolism in rats. Comp. Biochem. Phys. B. 121: 223–231 (1998)

    Article  CAS  Google Scholar 

  3. Kim HK, Choi S, Choi H. Suppression of hepatic fatty acid synthase by feeding alpha-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats. J. Nutr. Biochem. 15: 485–492 (2004)

    Article  CAS  Google Scholar 

  4. Sadi AM, Toda T, Oku H, Hokama S. Dietary effects of corn oil, oleic acid, perilla oil, and evening primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. Exp. Anim. Tokyo 45: 55–62 (1996)

    Article  CAS  Google Scholar 

  5. Onogi N, Okuno M, Komaki C, Moriwaki H, Kawamori T, Tanaka T, Mori H, Muto Y. Suppressing effect of perilla oil on azoxymethaneinduced foci of colonic aberrant crypts in rats. Carcinogenesis 17: 1291–1296 (1996)

    Article  CAS  Google Scholar 

  6. Shoda R, Matsueda K, Yamato S, Umeda N. Therapeutic efficacy of n-3 polyunsaturated fatty acid in experimental Crohn’s disease. J. Gastroenterol. 8: 98–101 (1995)

    Google Scholar 

  7. Yamamoto N, Saitoh M, Moriuchi A, Nomura M, Okuyama H. Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. J. Lipid Res. 28: 144–151 (1987)

    CAS  Google Scholar 

  8. Hong SH. Anti-atherogenic effects of perilla oil as dietary lipid source of n-3 fatty acid in apoE knockout mice. MS thesis, University of Pusan, Busan, Korea (2011)

    Google Scholar 

  9. Lee J, Song YO. Perilla oil rich in α-linolenic acid suppresses hepatic SREBPs and NF-κB expression in hypercholesterolemiainduced apolipoprotein E knockout mice. Food Sci. Biotechnol. 21: 807–813 (2012)

    Article  CAS  Google Scholar 

  10. Seong J, Song YO. Perilla oil rich in α-linolenic acid inhibits neuronal apoptosis and the expression of inflammation-mediator protein in apoE KO mice. Biocatal. Agric. Biotechnol. 1: 167–173 (2012)

    CAS  Google Scholar 

  11. Moon JH, Lee JT. Effects of convenience foods on overall satisfaction; focus on the Deluxe hotels. J. Hospital. Tour. Stud. 25: 206–219 (2007)

    Google Scholar 

  12. Mun YS, Jung EK, Joo NM, Yoon JY. A study on the intakes and perceptions of convenient breakfast. Korean J. Commun. Nutr. 16: 559–568 (2011)

    Article  Google Scholar 

  13. KHIDI. Food Industry Analysis Report 2011. Korea Health Industry Development Institute, Chungcheonbuk-do, Korea. p. 18 (2011)

    Google Scholar 

  14. Shin ES, Lee KA, Lee HK, Kim KBWR, Kim MJ, Byun MW, Lee JW, Kim JH, Ahn DH, Lyu ES. Effect of grain size and added water on quality characteristics of abalone porridge. J. Korean Soc. Food Sci. Nutr. 37: 245–250 (2008)

    Article  Google Scholar 

  15. Kim AJ, Kim MW, Woo NR. Processing of convenient rice gruels with sericultures. J. Korean Soc. Food Sci. Nutr. 20: 179–184 (2007)

    Google Scholar 

  16. Park BH, Cho HS. Quality characteristics of jook prepared with lotus root powder. Korean J. Economics Assoc. 47: 79–85 (2009)

    Google Scholar 

  17. Lee MK, Choi SH, Lim HS, Ahn JS. Quality characteristics of jook prepared with green laver powder. Korean J. Food Cookery Sci. 26: 552–558 (2010)

    Article  Google Scholar 

  18. Kim HK, Choi S, Choi H. Suppression of hepatic fatty acid synthase by feeding α-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats. J. Nutr. Biochem. 15: 485–492 (2004)

    Article  CAS  Google Scholar 

  19. Longvah T, Deostahle YG, Kumar PU. Nutritional and short term toxicological evaluation of perilla seed oil. Food Chem. 70: 13–16 (2000)

    Article  CAS  Google Scholar 

  20. Chang HH, Chen CS, Lin JY. Dietary perilla oil lowers serum lipids and ovalbumin-specific IgG1, but increases total IgE levels in ovalbumin-challenged mice. Food Chem. Toxicol. 47: 848–854 (2009)

    Article  CAS  Google Scholar 

  21. Ide T, Kobayashi H, Ashakumary L, Rouyer IA, Takahashi Y, Aoyama T, Hashimoto T, Mizugaki M. Comparative effects of perilla oil and fich oils on the activity and gene expression of fatty acid oxidation enzymes in rat liver. Biochim. Biophys. Acta 1485: 23–35 (2000)

    Article  CAS  Google Scholar 

  22. Hansson GK, Libby P. The immune response in atherosclerosis: A double-edged sword. Nat. Rev. Immunol. 6: 508–519 (2006)

    Article  CAS  Google Scholar 

  23. Shoda R, Matsueda K, Yamato S, Akiyama J, Muraoka A, Masaki N, Hayashi S, Shimojo E, Mahalanabis D. Therapeutic efficacy of polyunsaturated fatty acid on diarrhea and hypoglycemia in the rat fed with red kidney bean lectin. Digestion 22: 75–78 (1999)

    CAS  Google Scholar 

  24. Atakisi E, Atakisi O, Yaman H, Arslan I. Omega-3 fatty acid application reduces yolk and plasma cholesterol levels in Japanese quails. Food Chem. Toxicol. 47: 2590–2593 (2009)

    Article  CAS  Google Scholar 

  25. Park EJ, Cheong HS, Shin DS. A study on health condition and nutritional status of female university students in Masan area. J. Korean Soc. Food Sci. Nutr. 33: 1501–1514 (2004)

    Article  Google Scholar 

  26. KNS. Dietary Reference Intakes for Koreans 2010. 1st rev. The Korean Nutrition Society, Seoul, Korea (2010)

    Google Scholar 

  27. Yoon SJ, Hawer WD. A study on calorie and proximate components of traditional Korea gruel. J. Korean Soc. Food Sci. Nutr. 37: 879–885 (2008)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Food Science and Nutrition & Kimchi Research Institute, Pusan National University, Busan, 609-735, Korea

    Hyejin Jo, Mijeong Kim & Yeong Ok Song

  2. Nongshim R&D Center, Seongnam, Gyeonggi, 463-746, Korea

    Jihyun Lee & Hunjung Kim

Authors
  1. Hyejin Jo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mijeong Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jihyun Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hunjung Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yeong Ok Song
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yeong Ok Song.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jo, H., Kim, M., Lee, J. et al. Anti-atherogenic properties of emulsified perilla oil (EPO) in apo E KO mice and plasma lipid lowering effects of rice porridge containing EPO in healthy young adults. Food Sci Biotechnol 22, 79–85 (2013). https://doi.org/10.1007/s10068-013-0011-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-013-0011-2

Keywords

Search

Navigation