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Oral administration of loquat suppresses DMBA-induced breast cancer in rats

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Abstract

This study was to demonstrate whether loquat leaves protect against 7,12-dimethylbenz[α]anthracene (DMBA)-induced breast cancer in female rats. Rats were fed control diet (NC, DC), ethanol (DE), or water extract of loquat leaves (DW) until sacrifice. At 50 days of age, animals in the DC, DE, and DW groups were given a single intra-gastric dose of DMBA (50 mg/kg) dissolved in corn oil. Both the water and ethanol extracts of loquat leaves decreased the incidence of tumors, with water extract having the higher inhibitory effect. Ethanol extract significantly decreased the multiplicity of tumors. Loquat extracts significantly decreased tumor cell proliferation and the tumor grade based on the degree of tubule formation. These results suggest that both water and ethanol extracts of loquat leaves inhibit the development of breast cancer. Such inhibition may be based on the suppression of initiation and tumor cell proliferation.

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Authors and Affiliations

  1. Department of Food & Nutrition, Mokpo National University, Muan, Jeonnam, 534-729, Korea

    Min Sook Kim, Mi Kyoung You & Hyeon-A Kim

  2. Department of Medical Plant Resources, Mokpo National University, Muan, Jeonnam, 534-729, Korea

    Dong Young Rhyu

  3. Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Korea

    Kyu Shik Jeong

  4. Korea INSpharm Research Institute, Hwasun, Jeonnam, 519-882, Korea

    Yong Jae Kim & Hum Young Baek

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  1. Min Sook Kim
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  2. Mi Kyoung You
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  3. Dong Young Rhyu
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  4. Kyu Shik Jeong
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  5. Yong Jae Kim
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  7. Hyeon-A Kim
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Correspondence to Hyeon-A Kim.

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Kim, M.S., You, M.K., Rhyu, D.Y. et al. Oral administration of loquat suppresses DMBA-induced breast cancer in rats. Food Sci Biotechnol 20, 491–497 (2011). https://doi.org/10.1007/s10068-011-0068-8

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  • DOI: https://doi.org/10.1007/s10068-011-0068-8

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