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Neuronal cell protection and acetylcholinesterase inhibitory effect of the phenolics in chestnut inner skin

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Abstract

Chestnut inner skin was known to contain various phenolics as a potential antioxidant, and 3 phenolics (catechin, epicatechin, and gallic acid) were isolated. The relative antioxidant capacity of 3 phenolics in vitamin C equivalent antioxidant capacity (VCEAC) evaluated by ABTS assay was in decreasing order as follows: gallic acid>catechin>epicatechin>vitamin C. Gallic acid showed the highest inhibitory effect against acetylcholinesterase (AChE) in a dose-dependent manner and competitive inhibition. However catechins presented neuroprotective effects on amyloid β-induced neurotoxicity by MTT, lactate dehydrogenase (LDH) release, and neutral red uptake assays. Considering above data, it was supposed that gallic acid, catechin, and epicatechin have various antiamnesic effect in neurodegenerative diseases such as Alzheimer’s disease (AD). Therefore, it was strongly suggested that chestnut inner skin as phenolics-rich substance can be used in functional food supplement or pharmaceutical industry by utilization of wastage from valuable resources.

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Authors and Affiliations

  1. Department of Food Science and Technology, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, Gyeongnam, 660-701, Korea

    Ji Hye Kim, Gwi Nam Choi, Ji Hyun Kwak, Hee Rok Jeong & Ho Jin Heo

  2. Division of Special-purpose Trees, Korea Forest Research Institute, Suwon, Gyeonggi, 441-847, Korea

    Ji Hye Kim

  3. Department of Food Science and Technology, Institute of Life Science and Resources, Kyung Hee University, Yongin, Gyeonggi, 446-701, Korea

    Chang-Ho Jeong

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  1. Ji Hye Kim
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  2. Gwi Nam Choi
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Correspondence to Ho Jin Heo.

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Kim, J.H., Choi, G.N., Kwak, J.H. et al. Neuronal cell protection and acetylcholinesterase inhibitory effect of the phenolics in chestnut inner skin. Food Sci Biotechnol 20, 311–318 (2011). https://doi.org/10.1007/s10068-011-0044-3

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  • DOI: https://doi.org/10.1007/s10068-011-0044-3

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