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Effects of Cisapride on Oesophageal Transit of Solids in Patients with Progressive Systemic Sclerosis

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Abstract

In most patients with progressive systemic sclerosis (PSS) the oesophagus is affected. Reflux symptoms are most frequent, whilst dysphagia also occurs. Cisapride, a prokinetic agent, may enhance motility along the gastrointestinal tract. The effects of cisapride on oesophageal transit were evaluated in 12 PSS patient using a solid-phase radionuclide oesophageal transit study. Each PSS patient was given cisapride 10 mg or placebo orally three times a day in a random, double-blind, crossover fashion. The results show that cisapride does not seem to have any impact on oesophageal transit in patients with PSS.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Taiwan

    S.-J. Wang & W.-Y. Lin

  2. Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

    J.-L. Lan, D.-Y. Chen, Y.-H. Chen & T.-Y. Hsieh

  3. Taipei Medical University, Taipei, Taiwan, Taiwan

    J.-L. Lan

Authors
  1. S.-J. Wang
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  2. J.-L. Lan
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  3. J.-L. Lan
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  4. D.-Y. Chen
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  5. Y.-H. Chen
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  6. T.-Y. Hsieh
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  7. W.-Y. Lin
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Additional information

Received: 1 August 2000 / Accepted: 6 August 2001

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Wang, SJ., Lan, JL., Lan, JL. et al. Effects of Cisapride on Oesophageal Transit of Solids in Patients with Progressive Systemic Sclerosis. Clin Rheumatol 21, 43–45 (2002). https://doi.org/10.1007/s100670200010

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  • DOI: https://doi.org/10.1007/s100670200010

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