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18F-FDG-PET/CT: an accurate method to assess the activity of Takayasu’s arteritis

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Abstract

The objective of the study is to investigate the value of 18F-fluorodeoxyglucose–positron emission tomography/computed tomography (18F-FDG-PET/CT) for assessment of the activity of Takayasu’s arteritis (TA) and the correlation between acute-phase reactive proteins (ARPs) and standard uptake value (SUV). Analyses of the clinical characteristics and 42 18F-FDG-PET/CT scans in 39 TA patients were undertaken. The degree of FDG uptake in the blood vessel walls was assessed quantitatively by SUV. TA activity was analyzed by physician global assessment (PGA). Clinical and 18F-FDG-PET/CT characteristics were compared between patients with clinically active and clinically inactive TA. Maximum SUV (SUVmax), mean SUV (SUVmean), and SUV ratio (SUVratio) were significantly higher in the clinically active group than in the clinically inactive group (3.63 ± 1.96 vs. 1.82 ± 0.43, p = 0.007; 2.07 ± 0.71 vs. 1.43 ± 0.32, p = 0.009; 2.08 ± 1.17 vs. 0.95 ± 0.19, p = 0.000). Analyses of receiver operating characteristic (ROC) curves revealed a cutoff value of SUVmax of 2.21, with sensitivity and specificity of 86.2 and 90.0%, respectively, for clinically active TA. The SUVratio cutoff was 1.27 with a sensitivity and specificity of 79.3 and 100.0%, respectively. SUVratio was slightly superior to SUVmax and ARPs in the area under the curve (AUC) comparison. SUVmax and SUVratio showed a significant increasing trend with increasing US National Institutes of Health (NIH) score and levels of ARPs, interleukin-6, and serum amyloid-A protein. 18F-FDG-PET/CT is a promising non-invasive, quantitative measurement with high sensitivity and specificity for determining TA activity.

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Funding

This work was supported by the National Natural Science Foundation of China (81571571).

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Author notes

  1. Xiaojie Zhang and Jun Zhou contributed equally to this work.

Authors and Affiliations

  1. Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China

    Xiaojie Zhang, Ying Sun, Zongfei Ji & Lindi Jiang

  2. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China

    Jun Zhou & Hongcheng Shi

  3. Institute of Nuclear Medicine, Fudan University, Shanghai, China

    Jun Zhou & Hongcheng Shi

  4. Center of Clinical Epidemiology and Evidence-based Medicine, Fudan University, Shanghai, China

    Lindi Jiang

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  1. Xiaojie Zhang
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Correspondence to Lindi Jiang.

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The study protocol was approved by the ethics committee of Fudan University (Shanghai, China). All patients provided written informed consent to participate in the study.

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Zhang, X., Zhou, J., Sun, Y. et al. 18F-FDG-PET/CT: an accurate method to assess the activity of Takayasu’s arteritis. Clin Rheumatol 37, 1927–1935 (2018). https://doi.org/10.1007/s10067-017-3960-7

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  • DOI: https://doi.org/10.1007/s10067-017-3960-7

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