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Meniscal extrusion seen on ultrasonography affects the development of radiographic knee osteoarthritis: a 3-year prospective cohort study

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Abstract

The objective of this study is to determine whether meniscal extrusion (ME) of the medial meniscus on ultrasonography affects knee osteoarthritis (KOA) progression during 3-year follow-up. Two hundred seventy volunteers (70 men, 200 women; mean age 60.5 years) participated. Weight-bearing radiographs were evaluated. All subjects had medial radiographic KOA (Kellgren-Lawrence grade [KLG], ≥ 2) in at least one knee at baseline (BL). KLG 2 was defined as moderate KOA (MKOA); KLG 3 and 4 were defined as severe KOA (SKOA). Medial and lateral joint space width (MJSW and LJSW) were measured at the minimum width of femoro-tibial compartment. The medial and lateral osteophyte area (MOPA and LOPA) were measured. Rapid joint space narrowing progression (RP) was defined as ≥ 25% loss of JSW from BL. ME was measured at the medial knee joint space on the medial collateral ligament with ultrasonography. The optimal ME cut-off for RP was determined by ROC curve. The relationship between ME and the longitudinal change of radiographic parameters was elucidated by linear and logistic regression analysis. In the 460 OA knees at BL, both MOPA and LOPA increased, while only MJSW narrowed after 3 years. RP occurred in 25 knees among 281 MKOA knees and 42 among 179 SKOA knees. ME was associated with medial joint space narrowing only in the SKOA group, while the ME was associated with MOPA in the MKOA and SKOA groups. The cut-off value to detect RP was 5.5 mm only in the SKOA group. Ultrasonographic evaluation of medial ME was useful to detect radiographic KOA progression.

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Acknowledgements

We are extremely grateful to all participants in the Iwaki Health Promotion Project and to the staff of our department who conducted interviews and collected the data.

Funding

This study is funded by the Ministry of Education, Culture, Sports, Science and Technology of Japan (No. 18200044), the Japanese Society for the Promotion of Science (No. 21500676), Karoji Memorial Fund for Medical Research (No. 5310139302), and JOA-Subsidized Science Project Research from the Japanese Orthopaedic Association.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan

    Daisuke Chiba, Shugo Maeda, Eiji Sasaki, Seiya Ota & Yasuyuki Ishibashi

  2. Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan

    Seiya Ota & Shigeyuki Nakaji

  3. Department of Rehabilitation Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan

    Eiichi Tsuda

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  1. Daisuke Chiba
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Correspondence to Daisuke Chiba.

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Chiba, D., Maeda, S., Sasaki, E. et al. Meniscal extrusion seen on ultrasonography affects the development of radiographic knee osteoarthritis: a 3-year prospective cohort study. Clin Rheumatol 36, 2557–2564 (2017). https://doi.org/10.1007/s10067-017-3803-6

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  • DOI: https://doi.org/10.1007/s10067-017-3803-6

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