Abstract
Health-related quality of life (HRQoL) and well-being are concepts that attempt to objectively capture a person’s subjective perceptions of vitality and energy. Our objectives were to determine HRQoL and well-being in adult patients diagnosed with inflammatory myopathy who attended at our outpatient clinic and to investigate clinical and biological correlations with these concepts. Sixty-two patients (52 women), with a mean age of 50.7 years, were evaluated in this cross-sectional study—47 with dermatomyositis and 15 with polymyositis. Disease damage and activity were assessed with the International Myositis Assessment and Clinical Studies-validated instruments. Manual muscle testing was used to evaluate muscle strength. Quality of life was evaluated with the WHO instrument (WHO Quality of Life Measure (WHOQOL-BREF)), adapted for use in the Spanish population, and well-being with the WHO-Five Well-Being Index (WHO-5). t tests were conducted to examine differences in HRQoL and well-being outcomes in relation to several disease- and patient-related variables. Correlation analyses were performed with the Pearson correlation coefficient. None of the clinical or biological variables analyzed was significantly associated with a poorer HRQoL or well-being. No differences in HRQoL or WHO-5 well-being score were found between the two myositis subgroups (dermatomyositis vs. polymyositis). Disease activity and muscle weakness were negatively associated with the physical and environmental domains of the HRQoL, respectively (p < 0.002), but not with well-being. Disease duration did not have a significant impact on HRQoL or well-being. In adult patients with myositis, disease activity and muscle weakness are associated with poorer HRQoL in the physical health and environmental domains, respectively.
Similar content being viewed by others
Abbreviations
- ELISA:
-
Enzyme-linked immunosorbent assay
- HRQoL:
-
Health-related quality of life
- IMACS:
-
International Myositis Assessment and Clinical Studies
- MDI:
-
Myositis Damage Index
- MITAX:
-
Myositis Intention-to-Treat Activity Index
- MMT8:
-
Manual muscle testing
- MYOACT:
-
Myositis Disease Activity Assessment Visual Analog Scales
References
Dalakas MC, Hohlfeld R (2003) Polymyositis and dermatomyositis. Lancet 362:971–982
Bronner IM, van der Meulen MFG, de Visser M, Kalmijn S, van Venrooij WJ, Voskuyl AE et al (2006) Long-term outcome in polymyositis and dermatomyositis. Ann Rheum Dis 65:1456–1461
Hundley JL, Carroll CL, Lang W, Snively B, Feldman SR, Jorizzo JL (2006) Cutaneous symptoms of dermatomyositis significantly impact patients’ quality of life. J Am Acad Dermatol 54:217–220
Drouet B, Le Loët X, Vittecoq O, Nouvet G, Genevois A, Lauret P et al (1996) A study of long-term survival, functional outcome and quality of life in patients with polymyositis or dermatomyositis. Rev Rhum Engl Educ 63:321–330
Rider LG, Werth VP, Huber AM, Alexanderson H, Rao AP, Ruperto N, Herbelin L, Barohn R, Isenberg D, Miller FW (2011) Measures of adult and juvenile dermatomyositis, polymyositis, and inclusion body myositis: Physician and Patient/Parent Global Activity, Manual Muscle Testing (MMT), Health Assessment Questionnaire (HAQ)/Childhood Health Assessment Questionnaire (C-HAQ), Childhood Myositis Assessment Scale (CMAS), Myositis Disease Activity Assessment Tool (MDAAT), Disease Activity Score (DAS), Short Form 36 (SF-36), Child Health Questionnaire (CHQ), physician global damage, Myositis Damage Index (MDI), Quantitative Muscle Testing (QMT), Myositis Functional Index-2 (FI-2), Myositis Activities Profile (MAP), Inclusion Body Myositis Functional Rating Scale (IBMFRS), Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI), Cutaneous Assessment Tool (CAT), Dermatomyositis Skin Severity Index (DSSI), Skindex, and Dermatology Life Quality Index (DLQI). Arthritis Care Res (Hoboken) 63(Suppl 11):S118–S157
Chung YL, Mitchell HL, Houssien DA, Al-Mahrouki H, Carr AJ, Scott DL (2001) A comparative study of outcome in myositis and other musculoskeletal disorders assessed using the Nottingham health profile. Clin Exp Rheumatol 19:447–450
Alexanderson H, Lundberg IE (2007) Disease-specific quality indicators, outcome measures and guidelines in polymyositis and dermatomyositis. Clin Exp Rheumatol 25(suppl 47):S153–S158
Carroll CL, Lang W, Snively B, Feldman SR, Callen J, Jorizzo JL (2008) Development and validation of the Dermatomyositis Skin Severity Index. Br J Dermatol 158:345–350
Regardt M, Henriksson EW, Alexanderson H, Lundberg IE (2011) Patients with polymyositis or dermatomyositis have reduced grip force and health-related quality of life in comparison with reference values: an observational study. Rheumatology (Oxford) 50:578–585
Development of the World Health Organization WHOQOL-BREF quality of life assessment (1988) The WHOQOL Group. Psychol Med 28:551–558
Skevington SM, Lotfy M, O’Connell KA, WHOQOL Group (2004) The World Health Organisation’s WHOQOL-BREF quality of life assessment: psychometric properties and the results of the international field trial. A report from the WHOQOL Group. Qual Life Res 13:299–310
Asnani MR, Lipps GA, Reid ME (2009) Utility of WHOQOL-BREF in measuring quality of life in sickle cell disease. Health and Qual Life Outcome 7:75
Taylor WJ, Myers J, Simpson RT, Mcpherson KM, Weatherall M (2004) Quality of life of people with rheumatoid arthritis as measured by the World Health Organization Quality of Life Instrument, Short Form (WHOQOL-BREF): score distributions and psychometric properties. Arthritis Rheum 51:350–357
Bech P, Hamilton M (2012) Appendix 1: The clinical validity of rating scales for depression Copenhagen, in Clinical Psychometrics, John Wiley & Sons, Ltd, Chichester, West Sussex, UK. doi:10.1002/9781118511800.app1
Bech P, Olsen LR, Kjoller M, Rasmussen NK (2003) Measuring well-being rather than the absence of distress symptoms: a comparison of the SF-36 Mental Health subscale and the WHO-Five Well-Being Scale. Int J Methods Psychiatr Res 12:85–91
Bohan A, Peter JB (1975) Polymyositis and dermatomyositis (first of two parts). N Engl J Med 292:344–347
Bohan A, Peter JB (1975) Polymyositis and dermatomyositis (second of two parts). N Engl J Med 292:403–407
Selva-O'Callaghan A, Labrador-Horrillo M, Solans-Laque R, Simeon-Aznar CP, Martínez-Gómez X, Vilardell-Tarrés M (2006) Myositis-specific and myositis-associated antibodies in a series of eighty-eight Mediterranean patients with idiopathic inflammatory myopathy. Arthritis Rheum 55:791–798
International Myositis Assessment and Clinical Studies (IMACS) Group website. https://dirapps.niehs.nih.gov/imacs/. Accessed 24 May 2014
Isenberg DA, Allen E, Farewell V, Ehrenstein MR, Hanna MG, Lundberg IE et al (2004) International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease. Rheumatology (Oxford) 43:49–54
Harris-Love MO, Shrader JA, Koziol D, Pahlajani N, Jain M, Cintas HL et al (2009) Distribution and severity of weakness among patients with polymyositis, dermatomyositis and juvenile dermatomyositis. Rheumatology (Oxford) 48:134–139
Rider LG, Koziol D, Giannini EH, Jain MS, Smith MR, Whitney-Mahoney K et al (2010) Validation of manual muscle testing and a subset of eight muscles for adult and juvenile idiopathic inflammatory myopathies. Arthritis Care Res (Hoboken) 62:465–472
Lucas-Carrasco R (2012) The WHO, quality of life (WHOQOL) questionnaire: Spanish development and validation studies. Qual Life Res 21:161–165
Lucas-Carrasco R (2012) Reliability and validity of the Spanish version of the World Health Organization-Five Well-Being Index in elderly. Psychiatry Clin Neurosci 66:508–513
Cohen J (1988) Statistical power analysis for behavioral sciences, 2nd edn. Lawrence Erlbaum Associates, Hilldale
Sultan SM, Ioannou Y, Moss K, Isenberg DA (2002) Outcome in patients with idiopathic inflammatory myositis: morbidity and mortality. Rheumatology 41:22
Ponyi A, Borgulya G, Constantin T, Váncss A, Gergely L, Dankó K (2005) Functional outcome and quality of life in adult patients with idiopathic inflammatory myositis. Rheumatology 44:83–88
Burns TM, Graham CD, Rose MR, Simmons Z (2012) Quality of life and measures of quality of life in patients with neuromuscular disorders. Muscle Nerve 46:9–25
Graham CD, Rose MR, Grunfeld EA, Kyle SD, Weinman J (2011) A systematic review of quality of life in adults with muscle disease. J Neurol 258:1581–1592
Acknowledgments
We are grateful to Dr. Lisa Rider and Dr. Frederick W. Miller for their critical review of the manuscript and valuable suggestions. This study was funded in part by a grant (FIS/2012 PI12--01320) from the Spanish Ministry of Health and Consumer Affairs.
Disclosures
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Armadans-Tremolosa, I., Selva-O’Callaghan, A., Visauta-Vinacua, B. et al. Health-related quality of life and well-being in adults with idiopathic inflammatory myopathy. Clin Rheumatol 33, 1119–1125 (2014). https://doi.org/10.1007/s10067-014-2685-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-014-2685-0