Abstract
We describe two patients of alveolar haemorrhage in patients with eosinophilic granulomatosis with polyangiitis (eGPA). This report adds to the evidence that pulmonary haemorrhage is a rare but severe manifestation of eGPA. It may not be associated with positive ANCA antibodies and requires aggressive treatment.
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References
Sinico RA, Bottero P (2009) Churg-Strauss angiitis. Best Pract Res Clin Rheumatol 23(3):355
Kostianovsky A, Hauser T, Pagnoux C, Cohen P, Daugas E, Mouthon L et al (2012) Alveolar haemorrhage in ANCA-associated vasculitides: 80 patients’ features and prognostic factors. Clin Exp Rheumatol 30(1 Suppl 70):S77–S82
Della Rossa A, Baldini C, Tavoni A, Tognetti A, Neglia D, Sambuceti G et al (2002) Churg-Strauss syndrome: clinical and serological features of 19 patients from a single Italian centre. Rheumatology (Oxford) 41:1286–1294
Sinico RA, Di Toma L, Maggiore U, Bottero P, Radice A, Tosoni C et al (2005) Prevalence and clinical significance of anti-neutrophil cytoplasmic antibodies in Churg-Strauss. Arthritis Rheum 52:2926–2935
Comarmond C, Pagnoux C, Khellaf M, Cordier JF, Hamidou M, Viallard JF et al (2012) Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)—clinical characteristics and long-term follow-up of the 383 patients enrolled in the FVSG cohort. Arthritis Rheum. doi:10.1002/art.37721
Augusto V, Strehl JD, Bernhard M et al (2012) IgG4 immune response in Churg-Strauss syndrome. Ann Rheum Dis 71:390–393
Fishbein GA, Fishbein MC (2011) Lung vasculitis and alveolar haemorrhage: pathology. Semin Respir Crit Care Med 32:254–263
Worthy SA, Müller NL, Hansell DM, Flower CDR (1998) Churg-Strauss syndrome: the spectrum of pulmonary CT findings in 17 patients. AJR 170:297–300
Castañer E, Alguersuari A, Gallardo X, Andreu M, Pallardó Y, Mata JM et al (2010) When to suspect pulmonary vasculitis: radiologic and clinical clues. Radiographics 30:33–53
Guillevin L (2012) Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Presse Med 41(10):1004–1013
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Yalakki Jagadeesh L and Sangle SR are first authors
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Jagadeesh, L.Y., Sangle, S.R., Verma, H. et al. Alveolar haemorrhage in eosinophilic granulomatosis and polyangiitis (Churg-Strauss). Clin Rheumatol 33, 1177–1179 (2014). https://doi.org/10.1007/s10067-013-2484-z
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DOI: https://doi.org/10.1007/s10067-013-2484-z