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Single center study on ethnic and clinical features of Behcet’s disease in Moscow, Russia

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Abstract

For the purpose of investigating Behcet’s disease (BD) in Russia, 250 consecutive patients (177 men and 73 women) diagnosed with BD between 1990 and 2010 at the Research Institute of Rheumatology, Russian Academy of Medical Sciences in Moscow were enrolled in this study. The ethnic backgrounds of the patients were reported as follows: 23.2 % (58 cases) from Russia, 12.8 % (32 cases) from Azerbaijan, 14.4 % (36 cases) from Armenia, 8.8 % (22 cases) from Chechnya, and 21.6 % (55 cases) from Dagestan. The remaining 19.2 % (48 cases) were from other regions or of unknown origin. More than half (57.6 %) of the Behcet’s disease patients originated from Central Asia, specifically Azerbaijan, Armenia, Chechnya, and Dagestan. The mean age at disease onset was 31.5 ± 9.38 (13–60) years old, and the most typical initial manifestations were oral aphthous ulcers. Patients aged 20–39 years old were more commonly affected and displayed a wide clinical spectrum of the disease, with varieties of severe internal organ involvement. The manifestations observed throughout the course of the disease included oral aphthous ulcers (100 %), various cutaneous lesions (88.8 %), genital ulcers (81.2 %), and ocular lesions (54.0 %). Besides these, many organs/systems were implicated in patient cases, namely joint (53.2 %), vascular (25.2 %), neurological (8.0 %), gastrointestinal (25.2 %), and cardiac (5.6 %) systems. Involvements of ocular (p < 0.01) and skin (p < 0.01) lesions were more frequent in men than in women. HLA-B51 and HLA-A26 typing was performed in 127 patients and 508 healthy controls. HLA-B51 was found in 63.0 % of BD patients compared to 20.7 % of the healthy control subjects (p < 0.001), and HLA-A26 was present in 11.3 % of BD patients and 18.9 % of the control group. This study shows the presence of BD in Russia, and it is suggested that its prevalence in Central Asian people is much higher than that in White Russian.

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Acknowledgments

This work was supported by grants from the Japan Society for the Promotion of Science (JSPS) KAKENHI (grant numbers: 25462731, 23592602, and 22133010) and Russian Academy of Medical Science (RAMS) as part of study on Behcet’s disease in Russia.

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None.

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Author notes

  1. Anton Lennikov

    Present address: Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan

Authors and Affiliations

  1. Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Anton Lennikov, Kenichi Namba, Susumu Ishida & Shigeaki Ohno

  2. Research Institute of Rheumatology, Russian Academy of Medical Sciences (RAMS), Moscow, Russia

    Zemfira Alekberova, Regina Goloeva, Lev Denisov & Eugeny Nasonov

  3. Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan

    Nobuyoshi Kitaichi

  4. Department of Ocular Inflammation and Immunology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan

    Nobuyoshi Kitaichi & Susumu Ishida

  5. Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Mitsuhiro Takeno & Yoshiaki Ishigatsubo

  6. Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Nobuhisa Mizuki

Authors
  1. Anton Lennikov
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  2. Zemfira Alekberova
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Corresponding author

Correspondence to Nobuyoshi Kitaichi.

Additional information

Anton Lennikov and Zemfira Alekberova contributed equally to this work.

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Lennikov, A., Alekberova, Z., Goloeva, R. et al. Single center study on ethnic and clinical features of Behcet’s disease in Moscow, Russia. Clin Rheumatol 34, 321–327 (2015). https://doi.org/10.1007/s10067-013-2442-9

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  • DOI: https://doi.org/10.1007/s10067-013-2442-9

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