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Does Behcet’s disease associate with neuropathic pain syndrome and impaired well-being?

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Abstract

Previously peripheral neuropathy signs have been reported in inflammatory chronic diseases but the presence of neuropathic pain syndrome (NPS) in Behcet’s disease (BD) is unclear. The aim of this study was to investigate the association of BD with NPS and impaired quality of life and sleep quality. A total of 111 patients diagnosed as BD and 52 healthy controls were included. Pain severity was assessed by visual analogue scale (VAS) in rest and during activity. The NPS was diagnosed according to the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) index. The well-being and sleep disturbances of the groups were evaluated with Psychological General Well-Being (PGWB) Scale and Pittsburg Sleep Quality Index (PSQI). Although there were no one with NPS in healthy controls, the proportion of NPS in patients with BD was 19.8 % (p = 0.001). The VAS scores both in activity and at rest were higher in BD (p < 0.001). There was statistically significant decrease in total PGWB score in BD patients compared to healthy controls (p < 0.001). And significant increase in LANSS score was observed in patients with BD compared to healthy controls (p = 0.000). The total LANSS scores showed significant positive correlation with PSQI scores (r = 0.322) and negative correlation with total PGWB scores (r = -0.672) in patients with BD. We observed a positive correlation between LANSS and VAS (rest and activity) scores (r = 0.44, r = 0.42 respectively). The NPS seems to be associated with BD which should be taken into consideration in patients with neuropathic signs. The quality of life (QoL) and quality of sleep of the patients with BD were found to be impaired and this may be due to the presence of NPS.

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Authors and Affiliations

  1. Department of Therapy and Rehabilitation, Haymana Vocational Health School, Ankara University, Haymana, Ankara, Turkey

    Deniz Evcik

  2. Department of Physical Rehabilitation and Medicine, Antalya Training and Research Hospital, 07100, Soguksu, Antalya, Turkey

    Sebnem Koldas Dogan

  3. Department of Physical Rehabilitation and Medicine, School of Medicine, Ufuk University, Ankara, Turkey

    Saime Ay & Nihan Cuzdan

  4. Department of Dermatology, School of Medicine, Ufuk University, Ankara, Turkey

    Munevver Guven & Aysel Gurler

  5. Department of Dermatology, School of Medicine, Ankara University, Ankara, Turkey

    Ayse Boyvat

Authors
  1. Deniz Evcik
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  2. Sebnem Koldas Dogan
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  3. Saime Ay
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  4. Nihan Cuzdan
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  5. Munevver Guven
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  6. Aysel Gurler
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  7. Ayse Boyvat
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Correspondence to Sebnem Koldas Dogan.

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Evcik, D., Dogan, S.K., Ay, S. et al. Does Behcet’s disease associate with neuropathic pain syndrome and impaired well-being?. Clin Rheumatol 32, 33–36 (2013). https://doi.org/10.1007/s10067-012-2086-1

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  • DOI: https://doi.org/10.1007/s10067-012-2086-1

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