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Beyond the joints

Neurological involvement in rheumatoid arthritis

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Abstract

Although arthritis is the most notable component, rheumatoid arthritis (RA) is a systemic inflammatory disorder where extra-articular manifestations are common; among them, central and peripheral nervous system involvement is frequent and associated with significant morbidity and, in some cases, reduced life span. It may produce a myriad of symptoms and signs ranging from subtle numbness in a hand, to quadriparesis and sudden death. Central and peripheral neurologic manifestations may arise from structural damage produced by RA in diarthroidal joints, by the systemic inflammatory process of the disease itself or by the drugs used to treat it. Neurologic syndromes may appear suddenly or developed slowly through months, and emerge early or after years of having RA. Neurologic manifestations may be easily overlooked or incorrectly assigned to peripheral arthritis unless the attending physician is aware of these complications. In this article, we review neurologic involvement in RA patients with emphasis on clinical approach for early detection.

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Authors and Affiliations

  1. Unidad de Investigación en Enfermedades Crónico-Degenerativas, Guadalajara, Mexico

    Cesar Ramos-Remus, Sergio Duran-Barragan & Jose Dionisio Castillo-Ortiz

  2. Hospital General Regional 45, Instituto Mexicano del Seguro Social, Guadalajara, Mexico

    Cesar Ramos-Remus

  3. Centro Universitario del Sur, Universidad de Guadalajara, Cd. Guzmán, Mexico

    Sergio Duran-Barragan

  4. Colomos 2292, Providencia, Guadalajara, 44620, Mexico

    Cesar Ramos-Remus

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  1. Cesar Ramos-Remus
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  2. Sergio Duran-Barragan
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  3. Jose Dionisio Castillo-Ortiz
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Correspondence to Cesar Ramos-Remus.

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Ramos-Remus, C., Duran-Barragan, S. & Castillo-Ortiz, J.D. Beyond the joints. Clin Rheumatol 31, 1–12 (2012). https://doi.org/10.1007/s10067-011-1841-z

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