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Bone mineral density and frequency of osteoporosis among Vietnamese women with early rheumatoid arthritis

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Abstract

Generalised bone mineral density (BMD) reduction often occurs in established rheumatoid arthritis (RA); however, in early RA, there is a disagreement with regard to BMD in the femoral neck and lumbar spine, and there is no available information for the whole body. Therefore, the aims of this study were to investigate the BMD, frequency of osteoporosis and the risk factors for BMD reduction in Vietnamese women with early RA. BMD in the femoral neck, lumbar spine L1–4 and whole body was measured in 105 women with early RA (disease duration ≤3 years) and 105 age-matched healthy women (26–73 years) using a dual energy X-ray absorptiometry. Femoral neck and whole body BMD in women with RA were lower (p < 0.05) than controls, while lumbar spine BMD was similar between two groups. The frequency of osteoporosis in the femoral neck, lumbar spine and whole body in women with RA aged ≥50 were higher (p < 0.05) than controls: 41.8% versus 29.5%, 42.2% versus 37.7% and 37.1% versus 28%, respectively. There were associations between the frequencies of osteoporosis at all sites with postmenopausal status, glucocorticoid use, rheumatoid factor positivity and disease activity with lumbar spine BMD and disease disability with femoral neck and whole body BMD. In conclusion, women with early RA had significantly lower femoral neck and whole body BMD, but had similar lumbar spine BMD compared with controls. The frequency of osteoporosis at all sites was significantly higher in women with RA than controls, suggesting that assessment of BMD should be considered in women with early RA.

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Acknowledgments

The authors would like to thank the cooperation of all participants and the assistance of the staff of Outpatient Department at Bach Mai University Hospital who helped to conduct this study. This work was supported in part by a non-profit organization “Epidemiology and Clinical Research Information Network (ECRIN)”.

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Authors and Affiliations

  1. Rheumatology Division, Outpatient Department, Bach Mai University Hospital, 78 Avenue Giai Phong, Dong Da District, Hanoi, Vietnam

    Hanh-Hung Dao

  2. Endocrinology Division, Outpatient Department, Bach Mai University Hospital, Hanoi, Vietnam

    Quan-Trung Do

  3. Department of Young Leaders’ Program in HealthCare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Hanh-Hung Dao & Junichi Sakamoto

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  1. Hanh-Hung Dao
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  2. Quan-Trung Do
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  3. Junichi Sakamoto
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Correspondence to Hanh-Hung Dao.

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Dao, HH., Do, QT. & Sakamoto, J. Bone mineral density and frequency of osteoporosis among Vietnamese women with early rheumatoid arthritis. Clin Rheumatol 30, 1353–1361 (2011). https://doi.org/10.1007/s10067-011-1762-x

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  • DOI: https://doi.org/10.1007/s10067-011-1762-x

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