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Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery

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Abstract

Osteoarthritis (OA) is a disease that primarily results in the degeneration and destruction of the articular cartilage. However, synovitis that occurs secondarily by this primary phenomenon is crucial for both the structural and symptomatic progression of the disease. The Japanese Knee Osteoarthritis Measure (JKOM) was created as an outcome measure for Japanese patients with knee OA. This study was conducted to determine whether synovitis in knee OA correlates with the current disability of patients with knee OA who required total knee arthroplasty (TKA). Thirty-four Japanese patients with end-stage knee OA who required TKA were included in this study. The visual analog scale (VAS, 0–100) for pain and the JKOM score, as well as the Western Ontario and McMaster Universities Arthritis Index (WOMAC), were examined before the operation. Synovial samples were taken at the time of the operation. A histological analysis and gadolinium-enhanced magnetic resonance imaging (Gd-MRI) were conducted to evaluate synovitis. Correlations between the synovitis score evaluated by histological analysis and Gd-MRI with either the pain VAS score or the JKOM score were examined using Spearman’s rank correlation coefficient. Neither the synovitis scores evaluated by the histological analysis nor those by a Gd-MRI correlated with the pain VAS score (n = 34, r = 0.25, p = 0.18 and r = 0.08, p = 0.75, respectively) and WOMAC (n = 14, r = 0.35, p = 0.22 and r = 0.45, p = 0.16, respectively) of the patients. However, they significantly correlated with the JKOM score of the patients (n = 34, r = 0.55, p = 0.001 and r = 0.71, p = 0.001, respectively). The severity of synovitis in OA was closely correlated with the current functional impairment and disability of the patients receiving TKA with end-stage knee OA.

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Acknowledgement

We express our deep appreciation for Dr. Eri Arikawa-Hirasawa for her helpful comments and suggestions. This study was in part supported by a High Technology Research Center Grant from Ministry of Education, Culture, Sport, Science and Technology, Japan (to MI).

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Authors and Affiliations

  1. Department of Medicine for Motor Organ, Juntendo University Graduate School of Medicine, Tokyo, Japan

    Lizu Liu, Ippei Futami, Haruka Kaneko, Liang Ning, Zhuo Xu, Hiroshi Ikeda, Yuji Takazawa & Kazuo Kaneko

  2. Department of Orthopaedics, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Muneaki Ishijima, Ippei Futami, Haruka Kaneko, Mitsuaki Kubota, Takayuki Kawasaki, Hiroshi Ikeda, Yuji Takazawa, Yoshitomo Saita, Yuta Kimura, Shouyu Xu, Kazuo Kaneko & Hisashi Kurosawa

  3. Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan

    Muneaki Ishijima & Kazuo Kaneko

  4. Department of Clinical Pathology, Juntendo University Nerima Hospital, Tokyo, Japan

    Toshiharu Matsumoto

  5. Department of Anatomy and Life Structure, Juntendo University Graduate School of Medicine, Tokyo, Japan

    Hidetake Kurihara

Authors
  1. Lizu Liu
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  2. Muneaki Ishijima
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  3. Ippei Futami
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  8. Hidetake Kurihara
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  9. Liang Ning
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  11. Hiroshi Ikeda
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  13. Yoshitomo Saita
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  14. Yuta Kimura
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  15. Shouyu Xu
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  16. Kazuo Kaneko
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  17. Hisashi Kurosawa
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Corresponding author

Correspondence to Muneaki Ishijima.

Additional information

Lizu Liu and Muneaki Ishijima contributed equally to this work.

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Liu, L., Ishijima, M., Futami, I. et al. Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery. Clin Rheumatol 29, 1185–1190 (2010). https://doi.org/10.1007/s10067-010-1522-3

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  • DOI: https://doi.org/10.1007/s10067-010-1522-3

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