Abstract
A 64-year-old woman suffering from progressive amyloid A (AA) amyloidosis of the gastrointestinal (GI) tract, associated with active rheumatoid arthritis, was transferred to our hospital due to hypovolemic shock. Although intensive care, including treatment with prednisolone and methotrexate, improved the hypovolemic shock, paralytic ileus became dominant instead of the marked diarrhea, suggesting the terminal stage of AA amyloidosis of the GI tract. Thus, we administered tocilizumab, a humanized anti-interleukin 6 receptor antibody (8 mg/kg, repeated every 4 weeks). Two weeks after the first injection of tocilizumab, serum AA rapidly returned to their normal ranges in accordance with the amelioration of paralytic ileus and systemic joint pain. Surprisingly, after three courses of tocilizumab treatment, colon biopsy revealed no amyloid deposition. Tocilizumab is a promising agent to treat secondary AA amyloidosis by strongly suppressing serum AA levels.
References
Gillmore JD, Lovat LB, Persey MR, Pepys MB, Hawkins PN (2001) Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein. Lancet 358:24–29
Sattianayagam PT, Hawkins PN, Gillmore JD (2009) Systemic amyloidosis and the gastrointestinal tract. Nat Rev Gastroenterol Hepatol 6:608–617
Koivuniemi R, Paimela L, Suomalainen R, Leirisalo-Repo M (2008) Amyloidosis as a cause of death in patients with rheumatoid arthritis. Clin Exp Rheumatol 26:408–413
Sato H, Sakai T, Sugaya T, Otaki Y, Aoki K, Ishii K et al (2009) Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis. Clin Rheumatol 28:1113–1116
Nishida S, Hagihara K, Shima Y, Kawai M, Kuwahara Y, Arimitsu J et al (2009) Rapid improvement of AA amyloidosis with humanised anti-interleukin 6 receptor antibody treatment. Ann Rheum Dis 68:1235–1236
Ohsugi Y, Kishimoto T (2008) The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis. Exp Opin Biol Ther 8:669–681
Lachmann HJ, Goodman HJ, Gilbertson JA, Gallimore JR, Sabin CA, Gillmore JD et al (2007) Natural history and outcome in systemic AA amyloidosis. N Engl J Med 356:2361–2371
Nakamura T, Higashi S, Tomoda K, Tsukano M, Baba S (2007) Efficacy of etanercept in patients with AA amyloidosis secondary to rheumatoid arthritis. Clin Exp Rheumatol 25:518–522
Perry ME, Stirling A, Hunter JA (2008) Effect of etanercept on serum amyloid A protein (SAA) levels in patients with AA amyloidosis complicating inflammatory arthritis. Clin Rheumatol 27:923–925
Maini RN, Taylor PC, Szechinski J, Pavelka K, Broll J, Balint G et al (2006) Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 54:2817–2829
Hagihara K, Nishikawa T, Sugamata Y, Song J, Isobe T, Taga T et al (2005) Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression. Genes Cells 10:1051–1063
Gottenberg JE, Merle-Vincent F, Bentaberry F, Allanore Y, Berenbaum F, Fautrel B et al (2003) Anti-tumor necrosis factor alpha therapy in fifteen patients with AA amyloidosis secondary to inflammatory arthritides: a followup report of tolerability and efficacy. Arthritis Rheum 48:2019–2024
Okuda Y, Takasugi K (2006) Successful use of a humanized anti-interleukin-6 receptor antibody, tocilizumab, to treat amyloid A amyloidosis complicating juvenile idiopathic arthritis. Arthritis Rheum 54:2997–3000
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Inoue, D., Arima, H., Kawanami, C. et al. Excellent therapeutic effect of tocilizumab on intestinal amyloid a deposition secondary to active rheumatoid arthritis. Clin Rheumatol 29, 1195–1197 (2010). https://doi.org/10.1007/s10067-010-1422-6
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DOI: https://doi.org/10.1007/s10067-010-1422-6