Skip to main content

Advertisement

SpringerLink
Log in

A case of Hughes–Stovin syndrome associated with hyperhomocysteinemia

  • Case Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

We report a case of Hughes–Stovin syndrome (HSS) associated with hyperhomocysteinemia. A 24-year-old man who has no clinical features suggestive of Behcet’s disease was admitted for hemoptysis and dyspnea. Radiological and laboratory evaluation revealed multifocal pulmonary artery aneurysms involving bilateral segmental pulmonary artery, thrombi in right atrium and ventricle, and hyperhomocysteinemia. Accordingly, HSS associated with hyperhomocysteinemia was diagnosed, and the clinical and radiological improvement was achieved after treatment with prednisolone, warfarin, and folic acid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Lee J, Noh JW, Hwang JW et al (2008) Successful cyclophosphamide therapy with complete resolution of pulmonary artery aneurysm in Hughes-Stovin syndrome patient. Clin Rheumatol 27:1455–1458

    Article  PubMed  Google Scholar 

  2. Chalazonitis AN, Lachanis SB, Mitseas P et al (2009) Hughes-Stovin syndrome: a case report and review of the literature. Cases J 2:98

    Article  PubMed  Google Scholar 

  3. Ray JG, Kearon C, Yi Q, Sheridan P, Lonn E, Heart Outcomes Prevention Evaluation 2 (HOPE-2) Investigators (2007) Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial. Ann Intern Med 146:761–767

    PubMed  Google Scholar 

  4. Ates A, Aydintug O, Olmez U, Duzgun N, Duman M (2005) Serum homocysteine level is higher in Behcet’s disease with vascular involvement. Rheumatol Int 25:42–44

    Article  PubMed  Google Scholar 

  5. Aksu K, Turgan N, Oksel F et al (2001) Hyperhomocysteinaemia in Behcet’s disease. Rheumatology (Oxford) 40:687–690

    Article  CAS  Google Scholar 

  6. Sarican T, Ayabakan H, Turkmen S, Kalaslioglu V, Baran F, Yenice N (2007) Homocysteine: an activity marker in Behcet’s disease? J Dermatol Sci 45:121–126

    Article  CAS  PubMed  Google Scholar 

  7. Gonul M, Gul U, Kilinc C, Cakmak SK, Soylu S, Kilic A (2009) Homocysteine levels in patients with Behcet’s disease and patients with recurrent aphthous stomatitis. Clin Rheumatol 28:1153–1156

    Article  PubMed  Google Scholar 

  8. Tsai CL, Lu TC, Tsai KC, Chen WJ (2005) Hemoptysis caused by Hughes-Stovin syndrome. Am J Emerg Med 23:209–211

    Article  PubMed  Google Scholar 

Download references

Disclosures

None.

Author information

Authors and Affiliations

  1. Department of Internal Medicine and Institute of Health Science, Gyeongsang National University College of Medicine, 90, Chilam-dong, Jinju, 660-702, Republic of Korea

    Hyun-Ok Kim, Ho Cheol Kim, Yongwhi Park, Yong-Geun Jeong, Jae Hee Kim, Dae-Hong Jeon & Sang-Il Lee

  2. Department of Radiology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

    Kyoung-Nyeo Jeon

  3. Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Republic of Korea

    Hyun-Ok Kim, Ho Cheol Kim, Yongwhi Park, Yong-Geun Jeong, Jae Hee Kim, Dae-Hong Jeon, Kyoung-Nyeo Jeon & Sang-Il Lee

Authors
  1. Hyun-Ok Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ho Cheol Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yongwhi Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yong-Geun Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jae Hee Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dae-Hong Jeon
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kyoung-Nyeo Jeon
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sang-Il Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sang-Il Lee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, HO., Kim, H.C., Park, Y. et al. A case of Hughes–Stovin syndrome associated with hyperhomocysteinemia. Clin Rheumatol 29, 807–809 (2010). https://doi.org/10.1007/s10067-010-1393-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-010-1393-7

Keywords

Search

Navigation