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Altered adhesion molecules expression on peripheral blood mononuclear cells from patients with systemic sclerosis and clinical correlations

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Abstract

The aim of the study was to evaluate the expressions of adhesion molecules (AM) on peripheral blood mononuclear cells (PBMNC) from systemic sclerosis (SSc) patients. Thirty-one SSc patients (ACR) and 20 normal subjects were selected for the study. PBMNC were analyzed for LFA-1α, LFA-1β, ICAM-3, ICAM-1, and l-selectin expressions. ICAM-3 expression was decreased while ICAM-1 was increased on SSc PBMNC, compared to controls (p = 0.04 and 0.003, respectively). A positive association was found between LFA-1α (r = 0.37, p = 0.03), LFA-1β (r = 0.38, p = 0.002), ICAM-3 (r = 0.42, p = 0.01), and l-selectin (r = 0.38, p = 0.03) expressions and greater number of immunosuppressive drugs taken by SSc patients. Also, anti-centromeric positive SSc patients had lower expressions of LFA-1α, LFA-1β, ICAM-3, and l-selectin. Lower expression of ICAM-3 and higher expression of ICAM-1 suggest that AMs may be involved in the pathogenesis of scleroderma.

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Authors and Affiliations

  1. Massachusetts General Hospital, Harvard University, Cambridge, USA

    Heloisa Helena Braga Sawaya

  2. Rheumatology Division, University of São Paulo, São Paulo, Brazil

    Romy Beatriz Christmann de Souza & Claudia Goldenstein-Schainberg

  3. University of São Paulo, São Paulo, Brazil

    Solange Carrasco

  4. University of São Paulo, Av. Dr. Arnaldo, 455-3° andar-Reumatologia, sala 3107, São Paulo, 01246-000, SP, Brazil

    Romy Beatriz Christmann de Souza

Authors
  1. Heloisa Helena Braga Sawaya
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  2. Romy Beatriz Christmann de Souza
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  3. Solange Carrasco
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  4. Claudia Goldenstein-Schainberg
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Correspondence to Romy Beatriz Christmann de Souza.

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Sawaya, H.H.B., de Souza, R.B.C., Carrasco, S. et al. Altered adhesion molecules expression on peripheral blood mononuclear cells from patients with systemic sclerosis and clinical correlations. Clin Rheumatol 28, 847–851 (2009). https://doi.org/10.1007/s10067-009-1124-0

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  • DOI: https://doi.org/10.1007/s10067-009-1124-0

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