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Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction

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Abstract

Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diagnosis of RA and 42 age- and BMI-matched control were enrolled. The severity of RA was evaluated according to the number of destructed joints of overall 68 joints on plain radiographs (37 patients had mild RA and 53 had severe RA). Serum adiponectin level was significantly higher in the severe RA group (17.7 ± 6.7 μg/ml) than in the control (9.1 ± 3.8 μg/ml) and mild RA groups (13.9 ± 6.5 μg/ml) (control vs. mild RA group, P < 0.001; mild RA vs. severe RA group, P < 0.01). These results suggest that increased number of joint destruction is associated with hyperadiponectinemia in established RA patients.

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Acknowledgments

This work was supported by grants from the Ministry of Health, Labor, and Welfare of Japan.

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Authors and Affiliations

  1. Department of Orthopaedics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Kosuke Ebina, Wataru Ando, Makoto Hirao, Kazuya Oshima, Hideki Yoshikawa & Jun Hashimoto

  2. Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Kosuke Ebina, Atsunori Fukuhara, Morihiro Matsuda, Kazuhisa Maeda, Tadashi Nakamura & Iichiro Shimomura

  3. Biometrics Department, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Kagoshima, Kagoshima, 891-1394, Japan

    Tadashi Koga

  4. Division of Analysis for Pathophysiology, Institute of Clinical Research, National Hospital Organization Kure Medical Center, Kure, Hiroshima, 737-0023, Japan

    Morihiro Matsuda

  5. Department of Internal Medicine, National Hospital Organization Kure Medical Center, Kure, Hiroshima, 737-0023, Japan

    Morihiro Matsuda

  6. Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka, 543-0035, Japan

    Takahiro Ochi

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  1. Kosuke Ebina
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Correspondence to Jun Hashimoto.

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Ebina, K., Fukuhara, A., Ando, W. et al. Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction. Clin Rheumatol 28, 445–451 (2009). https://doi.org/10.1007/s10067-008-1074-y

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  • DOI: https://doi.org/10.1007/s10067-008-1074-y

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