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Serum levels of tissue inhibitor of metalloproteinase-1 and periarticular bone loss in early rheumatoid arthritis

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Abstract

We investigated the relationship between disease activity, serum biological mediators of joint damage, and periarticular bone loss in inflammatory arthritis. Patients with early inflammatory arthritis were recruited from a dedicated early arthritis clinic. At the time of recruitment, all had clinical evidence of synovitis. Patients were assessed at baseline and at 1-year follow-up. Periarticular and axial bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Serum levels of matrix metalloproteinase 1 and tissue inhibitor of metalloproteinases 1 (TIMP-1) were measured by enzyme-linked immunosorbent assay. A total 38 patients were included in the study. Twenty had rheumatoid arthritis (RA) and 18 had a seronegative spondylarthropathy (SpA). At baseline, periarticular hand BMD measurements were similar in RA and SpA. At 1 year, the mean periarticular hand BMD was significantly lower in RA (p < 0.05). Significant inverse correlations between both the Ritchie articular index and C-reactive protein levels and the change in periarticular hand BMD at 1 year were observed in RA (r = −0.792, p < 0.001 and r = −0.478, p = 0.045, respectively). Baseline TIMP-1 levels correlated with the change in periarticular hand BMD at 1 year in RA (r = 0.519, p = 0.02). At 1 year, radiographic measures of joint damage were highest in RA. Inverse correlations between the change in periarticular hand BMD and the changes in erosion score (r = −0.90, p = 0.04) were observed in patients demonstrating significant periarticular bone loss. Persistent disease activity was associated with increased periarticular bone loss in the hands in patients with RA, consistent with synovitis-mediated periarticular bone loss. The correlation between baseline TIMP-1 levels and periarticular bone loss over 1 year suggests that TIMP-1 may have utility as a biomarker of periarticular bone loss in early RA.

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Authors and Affiliations

  1. Department of Rheumatology, St Vincents University Hospital, Dublin, Ireland

    Eithne Murphy, Terence Rooney, Oliver FitzGerald & Barry Bresnihan

  2. Division of Immunology and Allergy, University Hospital, Geneva, Switzerland

    Pascale Roux-Lombard & Jean-Michel Dayer

Authors
  1. Eithne Murphy
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  2. Pascale Roux-Lombard
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  3. Terence Rooney
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  4. Oliver FitzGerald
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  5. Jean-Michel Dayer
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  6. Barry Bresnihan
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Correspondence to Barry Bresnihan.

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Murphy, E., Roux-Lombard, P., Rooney, T. et al. Serum levels of tissue inhibitor of metalloproteinase-1 and periarticular bone loss in early rheumatoid arthritis. Clin Rheumatol 28, 285–291 (2009). https://doi.org/10.1007/s10067-008-1037-3

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  • DOI: https://doi.org/10.1007/s10067-008-1037-3

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