Abstract
B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of patients with RA. Thirty-two RA patients and 16 controls were enrolled in this study, and CD22 expressions on B cells were analyzed by flow cytometry. In patients with RA, CD22+ B cells significantly decreased in comparison to the controls (ratio: P < 0.05). However, there was no correlation between this decrease and the clinical data. Interestingly, CD5+ CD22− B cells significantly increased in RA patients. The decrease in CD22+ B cells and increased in CD5+CD22− B cells play critical roles in the pathogenesis of RA mediated by the activation of B cells.
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References
Zvaifler NJ (1973) The immunopathology of joint inflammation in rheumatoid arthritis. Adv Immunol 16:256–336
Poe JC, Fujimoto M, Jansen PJ, Miller AS, Tedder TF (2000) CD22 forms a quaternary complex with SHIP, Grb2, and Shc.A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. J Biol Chem 275(23):17420–17427
Huck S, Le Corre R, Youinou P, Zouali M (2001) Expression of B cell receptor-associated signaling molecules in human lupus. Autoimmunity 33(3):213–224
Caligaris-Cappio F, Gobbi M, Janossy G (1982) Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia. J Exp Med 155(2):623–628
Youinou P, Mackenzie L, Broker BM, Isenberg DI, Drogou-Lelong A, Gentric A, Lydyard PM (1988) The importance of CD5-positive B cells in nonorgan-specific autoimmune diseases. Scand J Rheumatol Suppl 76:243–249
Hayakawa K, Hardy RR, Parks DA, Herzenberg LA (1983) The Ly-1 B cell subpopulation in normal, immunodefective and autoimmune mice. J Exp Med 157:202–218
Taniguchi O, Miyajima H, Hirano T, Noguchi M, Ueda A, Hashimoto H et al (1987) The Leu-1 B-cell subpopulation in patients with rheumatoid arthritis. J Clin Immunol 7(6):441–448
Sato S, Miller AS, Inaoki M, Bock CB, Jansen PJ, Tang ML et al (1996) CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity 5(6):551–562
Arnett FC, Edworthy SM, Bloch DA, Mcshane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatoid Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31(3):315–324
Nakiri Y, Kaneko H, Morimoto S, Suzuki J, Tokano Y, Hashimoto H (2003) Expression of NKB1 on peripheral T cells in patients with rheumatoid arthritis. Clin Rheumatol 22(4–5):305–308
Hardy RR, Hayakawa K (1994) CD5 B cells, a fetal B cell lineage. Adv Immunol 55:297–339
Peaker CJ (1994) Transmembrane signalling by the B-cell antigen receptor. Curr Opin Immunol 6(3):359–363
Sen G, Bikah G, Venkataraman C, Bondada S (1999) Negative regulation of antigen receptor-mediated signaling by constitutive association of CD5 with the SHP-1 protein tyrosine phosphatase in B-1 cells. Eur J Immunol 29(10):3319–3328
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Nakiri, Y., Minowa, K., Suzuki, J. et al. Expression of CD22 on peripheral B cells in patients with rheumatoid arthritis: relation to CD5-positive B cells. Clin Rheumatol 26, 1721–1723 (2007). https://doi.org/10.1007/s10067-007-0665-3
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DOI: https://doi.org/10.1007/s10067-007-0665-3