Abstract
Churg–Strauss syndrome (CSS) is an extremely rare disease, and even less common in women of childbearing age. Patients with severe disease or those who are un-responsive to corticosteroids are usually treated with cytotoxic drugs, especially cyclophosphmide. Intravenous immunoglobulin (IVIg) has became a promising, but not completely accepted, form of treatment for systemic vasculitis that is un-responsive to standard therapy. We report a case of a woman who presented with a CSS flare during pregnancy. Because of mono-neuritis, treatment with IVIg was instituted with successful results. Our case not only supports the beneficial effect of IVIg in CSS, but it also illustrates its successful and safe use in a patient who was pregnant. We discuss the indication of IVIg during the course of anti-neutrophil cytoplasm antigen (ANCA) vasculitis during the pregnancy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA et al (1990) The American College of Rheumatology 1990 criteria for the classification of Churg–Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 33:1094–1100
Noth I, Strek ME, Leff AR (2003) Churg–Strauss syndrome. Lancet 361:587–594
Churg A (2001) Recent advances in the diagnosis of Churg–Strauss syndrome. Mod Pathol 14:1284–1293
Richter C, Schnabel A, Csernok E, De Groot K, Reinhold-Keller E et al (1995) Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis with high-dose intravenous immunoglobulin. Clin Exp Immunol 101:2–7
Mouthon L (1999) Treatment of ANCA-positive systemic vasculitis with intravenous immunoglobins. Rev Med Interne 20(Suppl 4):431s–435s
Danieli MG, Cappelli M, Malcangi G, Logullo F, Salvi A et al (2004) Long term effectiveness of intravenous immunoglobulin in Churg–Strauss syndrome. Ann Rheum Dis 63:1649–1654
Hamilos DL, Christensen J (1991) Treatment of Churg–Strauss syndrome with high-dose intravenous immunoglobulin. J Allergy Clin Immunol 88:823–824
Armentia A, Fernandez A, Sanchez P, de la Fuente R, Sanchis E et al (1993) Asthma and vasculitis. Response to intravenous immunoglobulins. Allergol Immunopathol (Madr) 21:47–52
Levy Y, George J, Fabbrizzi F, Rotman P, Paz Y et al (1999) Marked improvement of Churg–Strauss vasculitis with intravenous gammaglobulins. South Med J 92:412–414
Rutberg SA, Ward DE, Roth BJ (2002) Churg–Strauss syndrome and pregnancy: successful treatment with intravenous immunoglobulin. J Clin Rheumatol 8:151–156
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hot, A., Perard, L., Coppere, B. et al. Marked improvement of Churg–Strauss vasculitis with intravenous gamma globulins during pregnancy. Clin Rheumatol 26, 2149–2151 (2007). https://doi.org/10.1007/s10067-007-0628-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-007-0628-8