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Behçet's disease in Lebanon: clinical profile, severity and two-decade comparison

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Abstract

The aim of this study is to describe the clinical features of Lebanese patients with Behçet's disease (BD) followed up at a tertiary care center in Lebanon. A retrospective review of medical records of 90 patients who fulfilled the International Study Group (ISG) criteria for diagnosis was performed. The clinical characteristics and severity score were compared with those reported from other populations of Arab and of Turkish origin using the same diagnostic criteria, and a comparison over two decades for the Lebanese population was made. The male-to-female ratio was 2.9:1, the mean age at onset, 25.4 years, and mean age at diagnosis, 29.2 years. One hundred percent of the patients had mouth ulceration; 72.2%, genital ulceration; 59.1%, arthritis; 55.7%, papulopustular skin lesion; 53.9%, ocular disease; 36.8%, vascular disease; 29.5%, erythema nodosum; and 23.0%, neurologic disease. The characteristics of our patient population are similar to that reported from other countries in the region. However, we found a higher prevalence of vascular and neurologic disease.

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References

  1. International Study Group for Behcet's Disease (1990) Criteria for diagnosis of Behcet's disease. Lancet 335(8697):1078–1080

    Google Scholar 

  2. al-Aboosi MM, al Salem M, Saadeh A, al-Jamal M, Hijawi M, Khammash M et al (1996) Behcet's disease: clinical study of Jordanian patients. Int J Dermatol 35(9):623–625

    Article  PubMed  CAS  Google Scholar 

  3. al-Dalaan AN, al Balaa SR, el Ramahi K, al-Kawi Z, Bohlega S, Bahabri S et al (1994) Behcet's disease in Saudi Arabia. J Rheumatol 21(4):658–661

    PubMed  CAS  Google Scholar 

  4. Al-Rawi ZS, Sharquie KE, Khalifa SJ, Al-Hadithi FM, Munir JJ (1986) Behcet's disease in Iraqi patients. Ann Rheum Dis 45(12):987–990

    Article  PubMed  CAS  Google Scholar 

  5. Ames PR, Steuer A, Pap A, Denman AM (2001) Thrombosis in Behcet's disease: a retrospective survey from a single UK centre. Rheumatology (Oxford) 40(6):652–655

    Article  CAS  Google Scholar 

  6. Arayssi T, Hamdan A (2004) New insights into the pathogenesis and therapy of Behcet's disease. Curr Opin Pharmacol 4(2):183–188

    Article  PubMed  CAS  Google Scholar 

  7. Danaci M, Gul S, Yazgan Y, Hulagu S, Uskent N (1996) Budd–Chiari syndrome as a complication of Behcet's syndrome. A case report. Angiology 47(1):93–95

    PubMed  CAS  Google Scholar 

  8. El-Ageb EM, Al-Maini MH, Al-Shukaily AK, Al-Farsi Y, Richens ER (2002) Clinical features of Behcet's disease in patients in the Sultanate of Oman; the significance of antiphospholipid antibodies? Rheumatol Int 21(5):176–181

    Article  PubMed  CAS  Google Scholar 

  9. Espinosa G, Cervera R, Reverter JC, Tassies D, Font J, Ingelmo M (2002) Vascular involvement in Behcet's disease. Isr Med Assoc J 4(8):614–616

    PubMed  Google Scholar 

  10. Ghayad E, Tohme A (1995) Behcet's disease in Lebanon: report of 100 cases. J Med Liban 43(1):2–7

    PubMed  CAS  Google Scholar 

  11. Jaber L, Milo G, Halpern GJ, Krause I, Weinberger A (2002) Prevalence of Behcet's disease in an Arab community in Israel. Ann Rheum Dis 61(4):365–366

    Article  PubMed  CAS  Google Scholar 

  12. Jabr FI, Shamseddine A, Uthman I, Chehal A, Taher A (2003) Thrombotic thrombocytopenic purpura in a patient with Behcet's disease. Arthritis Rheum 48(5):1468–1469 (author reply, p 1469)

    Article  PubMed  Google Scholar 

  13. Kidd D (2003) The prevalence of headache in Behcet's syndrome. Adv Exp Med Biol 528:377–379

    PubMed  Google Scholar 

  14. Krause I, Mader R, Sulkes J, Paul M, Uziel Y, Adawi M et al (2001) Behcet's disease in Israel: the influence of ethnic origin on disease expression and severity. J Rheumatol 28(5):1033–1036

    PubMed  CAS  Google Scholar 

  15. Kural-Seyahi E, Fresko I, Seyahi N, Ozyazgan Y, Mat C, Hamuryudan V et al (2003) The long-term mortality and morbidity of Behcet syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center. Medicine (Baltimore) 82(1):60–76

    Article  Google Scholar 

  16. Monastero R, Mannino M, Lopez G, Camarda C, Cannizzaro C, Camarda L K et al (2003) Prevalence of headache in patients with Behcet's disease without overt neurological involvement. Cephalalgia 23(2):105–108

    Article  PubMed  CAS  Google Scholar 

  17. Mousa AR, Marafie AA, Rifai KM, Dajani AI, Mukhtar MM (1986) Behcet's disease in Kuwait, Arabia. A report of 29 cases and a review. Scand J Rheumatol 15(3):310–332

    Article  PubMed  CAS  Google Scholar 

  18. Tamim H, Finan RR, Almawi WY (2002) Prevalence of two thrombophilia predisposing mutations: factor V G1691A (R506Q; Leiden) and prothrombin G20210A, among healthy Lebanese. Thromb Haemost 88(4):691–692

    PubMed  Google Scholar 

  19. Tohme A, Aoun N, El-Rassi B, Ghayad E (2003) Vascular manifestations of Behcet's disease. Eighteen cases among 140 patients. Joint Bone Spine 70(5):384–389

    Article  PubMed  Google Scholar 

  20. Yoshida A, Kawashima H, Motoyama Y, Shibui H, Kaburaki T, Shimizu K et al (2004) Comparison of patients with Behcet's disease in the 1980s and 1990s. Ophthalmology 111(4):810–815

    Article  PubMed  Google Scholar 

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Correspondence to Thurayya Arayssi.

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Hamdan, A., Mansour, W., Uthman, I. et al. Behçet's disease in Lebanon: clinical profile, severity and two-decade comparison. Clin Rheumatol 25, 364–367 (2006). https://doi.org/10.1007/s10067-005-0058-4

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  • DOI: https://doi.org/10.1007/s10067-005-0058-4

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