Abstract
Rheumatoid arthritis (RA) is a systemic inflammatory disease in which extra-articular involvement is not uncommon. Cardiac compromise may be frequent, although most often, it is clinically silent. Herein, two cases of RA-related endocarditis, one of which required valve replacement, are described. Etanercept was useful in controlling the articular and extra-articular RA compromise in both cases.
References
Abdel-Nasser AM, Rasker JJ, Valkenburg HA (1997) Epidemiological and clinical aspects relating to the variability of rheumatoid arthritis. Semin Arthritis Rheum 27:123–140
Chand EM, Freant LJ, Rubin JW (1999) Aortic valve rheumatoid nodules producing clinical aortic regurgitation and a review of the literature. Cardiovasc Pathol 8:333–338
Kitas G, Banks MJ, Bacon PB (2001) Cardiac involvement in rheumatoid disease. Clin Med 1:18–21
Van Doornum S, McColl G, Wicks IP (2002) Accelerated atherosclerosis: an extra-articular feature of rheumatoid arthritis. Arthritis Rheum 46:862–873
Cimmino MA, Salvarani C, Macchioni P et al (2000) Extra-articular manifestations in 587 Italian patients with rheumatoid arthritis. Rheumatol Int 19:213–217
Guedes C, Bianchi-Fior P, Cormier B, Barthelemy B, Rat AC, Boissiere MC (2001) Cardiac manifestations of rheumatoid arthritis: a case-control transesophageal echocardiography study in 30 patients. Arthritis Care Res 45:129–135
Abbas A, Byrd B (2000) Right-side heart failure due to right ventricular cavity obliteration due to rheumatoid nodules. Am J Cardiol 86:711–712
Iveson JM, Thadani U, Ionescu M, Wright V (1975) Aortic valve incompetence and replacement in rheumatoid arthritis. Ann Rheum Dis 34:312–320
Corrao S, Salli L, Arnone S et al (1995) Cardiac involvement in rheumatoid arthritis: evidence of silent heart disease. Eur Heart J 16:253–256
Ahmed SS, Arnett FC, Smith CA, Ahn C, Reveille JD (2001) The HLA-DRB1*0401 allele and the development of methotrexate-induced accelerated rheumatoid nodulosis: a follow-up study of 79 Caucasian patients with rheumatoid arthritis. Medicine (Baltimore) 80:271–278
Anaya JM, Correa PA, Mantilla RD, Arcos-Burgos M (2002) Rheumatoid arthritis association in Colombian population is restricted to HLA-DRB1*04 QRRAA alleles. Genes Immun 3:56–58
Combe B, Didry C, Gutierrez M, Anaya JM, Sany J (1993) Accelerated nodulosis and systemic manifestations during methotrexatre therapy for rheumatoid arthritis. Eur J Med 2:153–156
Kerstens PJ, Boerbooms AM, Jeurissen ME, Fast JH, Assmann KJ, van de Putte LB (1992) Accelerated nodulosis during low dose methotrexate therapy for rheumatoid arthritis. An analysis of ten cases. J Rheumatol 19:867–871
Dash S, Seibold JR, Tiku ML (1999) Successful treatment of methotrexate induced nodulosis with d-penicillamine. J Rheumatol 26:1396–1399
Cunnane G, Warnock M, Fye KH, Daikh DI (2002) Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis. Arthritis Rheum 47:445–449
Kaiser MJ, Bozonnat MC, Jorgensen C, Daures JP, Sany J (2002) Effect of etanercept on tenosynovitis and nodules in rheumatoid arthritis. Arthritis Rheum 46:559–560
Levine AJ, Dimitri WR, Bonser RS (1999) Aortic regurgitation in rheumatoid arthritis necessitating aortic valve replacement. Eur J Cardiothorac Surg 15:213–214
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Anaya, JM. Severe rheumatoid valvular heart disease. Clin Rheumatol 25, 743–745 (2006). https://doi.org/10.1007/s10067-005-0039-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-005-0039-7