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Systematic review of a marine nutriceutical supplement in clinical trials for arthritis: the effectiveness of the New Zealand green-lipped mussel Perna canaliculus

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Abstract

Background

Nutritional supplements, such as Seatone, which contain freeze-dried tissue from the New Zealand green-lipped mussel Perna canaliculus, are sold in many countries to relieve arthritic symptoms and to aid in the regeneration of arthritic and injured joints.

Methods

Searches for all published controlled trials on the clinical effectiveness of green-lipped mussel, as a nutritional supplement with potential health benefits for arthritis, were carried out from four independent databases. No language restrictions were imposed, and the review was undertaken from extracted data and was assessed critically according to predefined criteria by the authors.

Results

Reports of clinical studies, using freeze-dried mussel powder, show mixed outcome measures and are not conclusive, with only two of five randomized controlled trials attesting benefits for rheumatoid and osteoarthritis patients. Similarly, animal studies have likewise yielded mixed findings. In both these cases possibly due to the lack of stabilization of the omega-3 polyunsaturated fatty acids, now known to be the basis of anti-inflammatory activity.

Conclusion

There is little consistent and compelling evidence, to date, in the therapeutic use of freeze-dried green-lipped mussel powder products for rheumatoid or osteoarthritis treatment, particularly in comparison to other cheaper alternative nutriceutical supplements of proven efficacy. However, further investigations are necessary to determine whether green-lipped mussel supplements, such as Seatone, are therapeutic options in the management of arthritis.

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References

  1. Jeffs AG, Holland RC, Hooker SH, Hayden BJ (1999) Overview and bibliography of research on the greenshell mussel, Perna canaliculus from New Zealand water. J Shellfish Res 18:347–360

    Google Scholar 

  2. Croft JE (1980) Relief from arthritis: a safe and effective treatment from the ocean. Thorsons Publishers Ltd, Wellingborough, Northampton, UK

    Google Scholar 

  3. Billard H (1985) L'extrait de Perna canaliculus, la moule aux orles verts de nouvelle-zelande en rheumatologie (Extract of Perna canaliculus (New Zealand green-lipped mussel) in rheumatology). Gaz Méd 92:97–101

    Google Scholar 

  4. Walker-Bone K (2003) ‘Natural remedies’ in the treatment of osteoarthritis. Drugs Aging 20:517–526

    Article  PubMed  CAS  Google Scholar 

  5. Morelli V, Naquin C, Weaver V (2003) Alternative therapies for traditional disease states: osteoarthritis. Am Fam Phys 67:339–344

    Google Scholar 

  6. Jacobs JW, Rasker JJ, Van Reil PL, Gribnau FW, van de Putte LBW (1991) Alternative treatment methods in rheumatic diseases; a literature review. Ned Tijdschr Geneeskd 135:317–322

    PubMed  CAS  Google Scholar 

  7. Jadad AR, Moore RA, Carrol D, Jenkinson C, Reynolds DJM, Gavaghan DJ, McQuay HJ (1996) Assessing the quality of reports of randomised clinical trials: is blinding necessary? Control Clin Trials 17:1–12

    Article  PubMed  CAS  Google Scholar 

  8. Cullen JC, Flint MH, Leider J (1975) The effect of dried mussel extract on an induced polyarthritis in rats. N Z Med J 81:260–261

    PubMed  CAS  Google Scholar 

  9. Rainsford KD, Whitehouse MW (1980) Gastroprotective and anti-inflammatory properties of green lipped mussel (Perna canaliculus) preparation. Arzneim-Forsch 30:2128–2132

    CAS  Google Scholar 

  10. Miller TE, Ormrod D (1980) The anti-inflammatory activity of Perna canaliculus (NZ green lipped mussel). N Z Med J 92:187–193

    PubMed  CAS  Google Scholar 

  11. Palmer DG (1980) Anti-inflammatory effects of mussel extracts. N Z Med J 92:328

    Google Scholar 

  12. Couch RA, Ormrod DJ, Miller TE, Watkins WB (1982) Anti-inflammatory activity in fractionated extract of green-lipped mussel. N Z Med J 95:803–806

    PubMed  CAS  Google Scholar 

  13. Kosuge T, Tsuji K, Ishida H, Yamaguchi T (1986) Isolation of an anti-histaminic substance from green-lipped mussel (Perna canaliculus). Chem Pharm Bull 34:4825–4828

    PubMed  CAS  Google Scholar 

  14. Miller TE, Dodd J, Ormrod DJ, Geddes R (1993) Anti-inflammatory activity of glycogen extracted from Perna canaliculus (NZ green-lipped mussel). Agents Actions 38:C139–C142

    Article  PubMed  CAS  Google Scholar 

  15. Bui L, Bierer TL (2001) Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs. Vet Ther 2:101–111

    Google Scholar 

  16. Bierer TL, Bui LM (2002) Improvement of arthritic signs in dogs fed green-lipped mussel (Perna canaliculus). J Nutr 132:1634S–1636S

    PubMed  CAS  Google Scholar 

  17. Miller T, Wu H (1984) In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract. N Z Med J 97:355–357

    PubMed  CAS  Google Scholar 

  18. Murphy KJ, Mooney BD, Mann NJ, Nichols PD, Sinclair AJ (2002) Lipid, FA, and sterol composition of New Zealand green-lipped mussel (Perna canaliculus) and Tasmanian blue mussel (Mytilis edulis). Lipids 37:587–595

    Article  PubMed  CAS  Google Scholar 

  19. Murphy KJ, Mann NJ, Sinclair AJ (2003) Fatty acid and sterol composition of frozen and freeze-dried New Zealand green lipped mussel (Perna canaliculus) from three sites in New Zealand. Asia Pac J Clin Nutr 12:50–60

    PubMed  CAS  Google Scholar 

  20. Whitehouse MW, Macrides TA, Kalafatis N, Betts WH, Haynes DR, Broardbent J (1997) Anti-inflammatory activity of a lipid fraction (lyprinol) from NZ green-lipped mussel. Inflam Pharmacol 5:237–248

    Article  CAS  Google Scholar 

  21. Sinclair AJ, Murphy KJ, Li D (2000) Marine lipids: overview “news insights and lipid composition of Lyprinol”. Allerg Immunol 32:261–271

    CAS  Google Scholar 

  22. Halpern GM (2000) Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol). Allerg Immunol 32:272–278

    CAS  Google Scholar 

  23. Highton, TC, McArthur AW (1975) Pilot study on the effect of New Zealand green mussel on rheumatoid arthritis. N Z Med J 81:261–262

    PubMed  CAS  Google Scholar 

  24. Gibson RG, Gibson SLM, Conway V, Chappell D (1980) Perna canaliculus in the treatment of arthritis. Practitioner 224:955–960

    PubMed  CAS  Google Scholar 

  25. Huskisson EC, Scott J, Bryans R (1981) Seatone is ineffective in rheumatoid arthritis. Br Med J 282:1358–1359

    CAS  Google Scholar 

  26. Caughey DE, Grigor RR, Caughey EB, Young P, Gow PJ, Stewart AW (1983) Perna canaliculus in the treatment of rheumatoid arthritis. Eur J Rheumatol Inflamm 6:197–200

    PubMed  CAS  Google Scholar 

  27. Larkin JG, Capell HA, Sturrock RD (1985) Seatone in rheumatoid arthritis: a six-month placebo-controlled study. Ann Rheum Dis 44:199–201

    PubMed  CAS  Google Scholar 

  28. Audeval B, Bouchacourt P (1986) Etude contrôlée, en double aveugle contre placebo, de l'extrait de moule Perna canaliculus (moule aux orles verts) dans la gonarthose (Double blind, placebo-controlled study of the mussel Perna canaliculus (New Zealand green-lipped mussel) in arthritis of the knee). La Gazette 93:111–116

    Google Scholar 

  29. Gibson SLM, Gibson RG (1998) The treatment of arthritis with a lipid extract of Perna canaliculus: a randomised trial. Comp Ther Med 6:122–126

    Article  Google Scholar 

  30. Gibson SLM (2000) The effect of a lipid extract of the New Zealand green-lipped mussel in three cases of arthritis. J Altern Complement Med 6:351–354

    Article  PubMed  CAS  Google Scholar 

  31. Gibson RG, Gibson SLM (1981) Green-lipped mussel extract in arthritis. Lancet 1:439

    Article  PubMed  CAS  Google Scholar 

  32. Gibson RG, Gibson SLM (1981) Seatone in arthritis. Br Med J 282:1795

    CAS  Google Scholar 

  33. Gibson RG, Gibson SLM (1981) Seatone in arthritis. Br Med J 283:1472

    Article  CAS  Google Scholar 

  34. Gibson RG, Gibson SLM (1981) New Zealand green-lipped mussel extract (Seatone) in rheumatoid arthritis. N Z Med J 94:67–68

    PubMed  CAS  Google Scholar 

  35. Gibson RG, Gibson SLM (1985) Seatone in rheumatoid arthritis. Ann Rheum Dis 44:645–646

    PubMed  CAS  Google Scholar 

  36. Cappell HA, Rennie JAN, Rooney PJ, Murdoch RM, Hole DJ, Dick WC, Bucharian WW (1979) Patient compliance: a novel method of testing non-steroid antiinflammatory analgesics in rheumatoid arthritis. J Rheumatol 6:584–593

    PubMed  Google Scholar 

  37. Kendall RV, Lawson JW, Hurley LA (2000) New research and a clinical report on the use of Perna canaliculus in the management of arthritis. Townsend Lett Dr Patients 204:98–111

    Google Scholar 

  38. Bucci LR (1994) Chondroprotective agents: glucosamine salts and chondroitin sulphates. Townsend Lett Dr 1:52–54

    Google Scholar 

  39. Curtis CL, Harwood JL, Dent CM, Caterson B (2004) Biological basis for the benefit of nutriceutical supplementation in arthritis. Drug Discov Today 9:165–172

    Article  PubMed  CAS  Google Scholar 

  40. Whitehouse MW, Butters DE (2003) Combination anti-inflammatory therapy: synergism in rats of NSAIDs/corticosteroids with some herbal/animal products. Inflammopharmacology 11:453–464

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

C. S. C. was supported by a research fellowship from The Boots Company, Nottingham, UK.

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Authors and Affiliations

  1. Complementary Medicine, Institute of Health and Social Care Research, Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter, EX2 4NT, UK

    Christopher S. Cobb & Edzard Ernst

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  1. Christopher S. Cobb
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  2. Edzard Ernst
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Correspondence to Edzard Ernst.

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Cobb, C.S., Ernst, E. Systematic review of a marine nutriceutical supplement in clinical trials for arthritis: the effectiveness of the New Zealand green-lipped mussel Perna canaliculus . Clin Rheumatol 25, 275–284 (2006). https://doi.org/10.1007/s10067-005-0001-8

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  • DOI: https://doi.org/10.1007/s10067-005-0001-8

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