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Association between systemic sclerosis and breast cancer: eight new cases and review of the literature

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Abstract

Several studies have demonstrated an increased frequency of cancer in patients with systemic sclerosis (SSc), specially lung and breast cancers. The pathogenesis of the association between SSc and cancer is not fully established. The aim of this study was to describe new cases of the association between SSc and breast cancer and to perform a review of the literature. We retrospectively studied the medical files of eight patients followed in our institution for SSc and breast cancer. We analyzed them with data available in the literature for a total of 46 patients. Cutaneous extension of SSc was clearly mentioned in 17 cases: the SSc was limited in 10 cases and diffuse in 7 cases The median age at the diagnosis of cancer was 54 years (range: 40–71). The median duration between SSc onset and breast cancer diagnosis was 11.5 months (range: 0–288). The duration between SSc onset and breast cancer diagnosis was ≤12 months in 27 of 44 patients (61.4%), and in 11 (25%) of them the diagnosis of both diseases was made simultaneously. It was clearly mentioned for 35 patients whether the diagnosis of breast cancer was made before or after the onset of SSc. The diagnosis of breast cancer was made before SSc onset in 17 of 35 patients (48.6%) and after SSc onset in 18 of 35 patients (51.4%). For 33 patients, the follow-up was available: 18 (54.5%) died, 11 (33.3%) of them within the 1st year after the diagnosis of the cancer. For none of the patients did the anticancer treatment improve the SSc. The close temporal relationship between SSc onset and breast cancer diagnosis is highly suggestive of a pathophysiological link. SSc is probably not a paraneoplastic disease since the anticancer treatment has no influence on the evolution of SSc. However, it can be suggested that SSc could be a disease facilitating breast cancer and/or metastases development.

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References

  1. LeRoy EC, Black C, Fleischmajer R, et al. (1988) Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 15:202–205

    CAS  PubMed  Google Scholar 

  2. Fleischmajer R (1977) The pathophysiology of scleroderma. Int J Dermatol 16:321–328

    Google Scholar 

  3. Hill CL, Nguyen AM, Roder D, Roberts-Thomson P (2003) Risk of cancer in patients with scleroderma: a population based cohort study. Ann Rheum Dis 62:728–731

    Article  CAS  PubMed  Google Scholar 

  4. Duncan SC, Winkelmann RK (1979) Cancer and scleroderma. Arch Dermatol 115:950–955

    CAS  PubMed  Google Scholar 

  5. Roumm AD, Medsger TA Jr (1985) Cancer and systemic sclerosis. An epidemiologic study. Arthritis Rheum 28:1336–1340

    CAS  PubMed  Google Scholar 

  6. Rosenthal AK, McLaughlin JK, Gridley G, Nyren O (1995) Incidence of cancer among patients with systemic sclerosis. Cancer 76:910–914

    CAS  PubMed  Google Scholar 

  7. Rosenthal AK, McLaughlin JK, Linet MS, Persson I (1993) Scleroderma and malignancy: an epidemiological study. Ann Rheum Dis 52:531–533

    CAS  PubMed  Google Scholar 

  8. Abu-Shakra M, Guillemin F, Lee P (1993) Cancer in systemic sclerosis. Arthritis Rheum 36:460–464

    CAS  PubMed  Google Scholar 

  9. Lee P, Alderdice C, Wilkinson S, Keystone EC, Urowitz MB, Gladman DD (1983) Malignancy in progressive systemic sclerosis, association with breast carcinoma. J Rheumatol 10:665–666

    CAS  PubMed  Google Scholar 

  10. Masi AT, Rodnan GP, Medsger TA Jr, et al. (1980) Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum 23:581–590

    PubMed  Google Scholar 

  11. Scarff RW, Torloni H (1968) Histological typing of breast tumors. International histological classification of tumors, n°2. World Health Organization, Geneva, pp 13–20

  12. Talbott JH, Barrocas M (1979) Progressive systemic sclerosis (PSS) and malignancy, pulmonary and non-pulmonary. Medicine (Baltimore) 58:182–207

    Google Scholar 

  13. Forbes AM, Woodrow JC, Verbov JL, Graham RM (1989) Carcinoma of breast and scleroderma: four further cases and a literature review. Br J Rheumatol 28:65–69

    CAS  PubMed  Google Scholar 

  14. Booton R, Jeffrey R, Prabhu PN (1999) Systemic sclerosis and scleroderma renal crisis in association with carcinoma of the breast. Am J Kidney Dis 34:937–941

    CAS  PubMed  Google Scholar 

  15. Darras-Joly C, Wechsler B, Bletry O, Piette JC (1999) De novo systemic sclerosis after radiotherapy: a report of 3 cases. J Rheumatol 22:2265–2267

    Google Scholar 

  16. Bleasel NR, Stapleton KM, Commens C, Ahern VA (1999) Radiation-induced localized scleroderma in breast cancer patients. Australas J Dermatol 40:99–102

    Article  CAS  PubMed  Google Scholar 

  17. Bielefeld P, Meyer P, Caillot D, et al. (1996) Systemic scleroderma and cancers: 21 cases and review of the literature (in French). Rev Med Interne 17:810–813

    Article  CAS  PubMed  Google Scholar 

  18. Hassett C, Harnett P, Manolios N (2001) Scleroderma in association with the use of docetaxel (taxotere) for breast cancer. Clin Exp Rheumatol 19:197–200

    CAS  PubMed  Google Scholar 

  19. Davies DA, Cohen PR, McNeese MD, Duvic M (1996) Localized scleroderma in breast cancer patients treated with supervoltage external beam radiation. J Am Acad Dermatol 35:923–927

    PubMed  Google Scholar 

  20. Ross JG, Hussey DH, Mayr NA, Davis CS (1993) Acute and late reactions to radiation in patients with collagen vascular diseases. Cancer 71:3744–3752

    CAS  PubMed  Google Scholar 

  21. Hesselstrand R, Scheja A, Akesson A (1998) Mortality and causes of death in a Swedish series of systemic sclerosis patients. Ann Rheum Dis 57:682–686

    CAS  PubMed  Google Scholar 

  22. Rattner JB, Rees J, Whitehead CM, et al. (1997) High frequency of neoplasia in patients with autoantibodies to centromere protein CENP-F. Clin Invest Med 20:308–319

    CAS  PubMed  Google Scholar 

  23. Kyndt X, Hebbar M, Queyrel V, Hachulla E, Hatron PY, Devulder B (1997) Systemic sclerosis and malignancy: assessment of risk factors associated with the development of cancer in 123 patients with systemic sclerosis. Rev Med Interne 18:1–5

    Google Scholar 

  24. Derk CT, Sakkas LI, Rasheed M, Artlett C, Jimenez S (2003) Autoantibodies in patients with systemic sclerosis and cancer: a case-control study. J Rheumatol 30:1994–1996

    CAS  PubMed  Google Scholar 

  25. Bevilacqua M, Pober J, Mendrick D, Cotran R, Gimbrone M (1987) Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci U S A 84:9238–9242

    CAS  PubMed  Google Scholar 

  26. Hebbar M, Lassalle P, Janin A, et al. (1995) E-selectin expression in salivary endothelial cells and sera of patients with systemic sclerosis. Role of resident mast cell-derivated tumor necrosis factor alpha (TNF). Arthritis Rheum 38:406–412

    CAS  PubMed  Google Scholar 

  27. Claman H, Giorno RC, Seibold JR (1991) Endothelial and fibroblastic activation in scleroderma. The myth of the “uninvolved” skin. Arthritis Rheum 34:1495–1501

    CAS  PubMed  Google Scholar 

  28. Zetter B (1993) Adhesion molecules in tumor metastasis. Semin Cancer Biol 4:219–229

    CAS  PubMed  Google Scholar 

  29. Recchi MA, Hebbar M, Hornez L, Harduin-Lepers A, Peyrat JP, Delannoy P (1998) Multiplex reverse transcriptase polymerase chain reaction assessment of sialyltransferases expression in human breast cancer. Cancer Res 58:4066–4070

    CAS  PubMed  Google Scholar 

  30. Hebbar M, Révillion F, Louchez MM, Fournier C, Bonneterre J, Peyrat JP (1999) Prognostic value of circulating soluble E-Selectin in node-negative breast cancer patients. Clin Cancer Res 5:1427–1435

    CAS  PubMed  Google Scholar 

  31. Hebbar M, Révillion F, Louchez MM, et al. (1998) The relationship between concentrations of circulating soluble E-selectin and clinical, biological, and pathological features in patients with breast cancer. Clin Cancer Res 4:373–380

    CAS  PubMed  Google Scholar 

  32. Hamada J, Cavanaugh PG, Lotan O (1994) Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothelial cells derived from target organs for metastasis. Br J Cancer 66:349–354

    Google Scholar 

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Authors and Affiliations

  1. Service de Médecine Interne, CHRU, Hôpital Claude Huriez, 1 Place Verdun, 59037, Lille, France

    David Launay, Rozenn Le Berre, Pierre-Yves Hatron, Eric Hachulla, Bernard Devulder & Mohamed Hebbar

  2. Laboratoire d’Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France

    Jean-Philippe Peyrat

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  1. David Launay
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  2. Rozenn Le Berre
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  3. Pierre-Yves Hatron
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  4. Jean-Philippe Peyrat
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  5. Eric Hachulla
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  6. Bernard Devulder
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  7. Mohamed Hebbar
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Correspondence to Mohamed Hebbar.

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The first two authors have contributed equally to this work

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Launay, D., Le Berre, R., Hatron, PY. et al. Association between systemic sclerosis and breast cancer: eight new cases and review of the literature. Clin Rheumatol 23, 516–522 (2004). https://doi.org/10.1007/s10067-004-0940-5

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  • DOI: https://doi.org/10.1007/s10067-004-0940-5

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