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Autoimmune manifestations in common variable immunodeficiency

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Abstract

Common variable immunodeficiency (CVID) is a disorder characterized by decreased serum immunoglobulin concentrations and increased incidence of recurrent infections. Interestingly 20–25% of patients with CVID develop clinical features suggestive of an autoimmune disease. Although this association is well established, the immunodeficiency background of CVID patients manifesting autoimmune disorders is often overlooked. This study describes three CVID patients displaying a variety of autoimmune manifestations. The pathophysiologic mechanisms of autoimmunity in CVID are also reviewed.

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Acknowledgements

We thank Professor H.M. Moutsopoulos, M.D., for his valuable instructions and comments.

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Authors and Affiliations

  1. Department of Pathophysiology, Medical School, National University of Athens, M. Asias 75, Goudi, 11527 , Athens, Greece

    Stavroula Giannouli, Fotini Soliotis & Michalis Voulgarelis

  2. Department of Haemopathology, Evagelismos Hospital, Athens, Greece

    Dimitra Anagnostou

Authors
  1. Stavroula Giannouli
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  2. Dimitra Anagnostou
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  3. Fotini Soliotis
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  4. Michalis Voulgarelis
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Correspondence to Michalis Voulgarelis.

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Giannouli, S., Anagnostou, D., Soliotis, F. et al. Autoimmune manifestations in common variable immunodeficiency. Clin Rheumatol 23, 449–452 (2004). https://doi.org/10.1007/s10067-004-0886-7

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  • DOI: https://doi.org/10.1007/s10067-004-0886-7

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