Abstract
Storage of oligosaccharides due to a deficiency of α-mannosidase can lead to joint destruction in children and young adults. Treating hip destruction with a prosthesis might be successful in some of these patients, although diminished bone quality increases the risk of loosening of the prosthesis.
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Acknowledgements
We thank Dr. Dag Malm, Tromsø University, Norway, for information on mannosidosis and Dr. P. Besselaar, orthopedic surgeon AMC, Amsterdam, for giving us the early medical history.
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Gerards, A.H., Winia, W.P.C.A., Westerga, J. et al. Destructive joint disease in α-mannosidosis. A case report and review of the literature. Clin Rheumatol 23, 40–42 (2004). https://doi.org/10.1007/s10067-003-0770-x
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DOI: https://doi.org/10.1007/s10067-003-0770-x