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Lack of association of MTHFR gene polymorphisms with the risk of osteonecrosis of the femoral head in a Korean population

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Molecules and Cells

Abstract

Some studies have suggested that coagulation disorders may be implicated in osteonecrosis of the femoral head (ONFH). The C677T polymorphism of the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene has been postulated to be a genetic risk factor for venous thromboembolism and osteonecrosis in Caucasians, but this relationship has not been established in other populations. In this study, we conducted case-control analysis of whether MTHFR polymorphisms are associated with ONFH in Korean patients. Fifteen single nucleotide polymorphisms (SNPs) were selected and genotyped in 443 ONFH patients and 273 control subjects using the TaqMan 5′ allelic discrimination assay. Comparison of ONFH and control subjects using logistic regression models revealed no statistically significant differences in the frequencies of the MTHFR polymorphisms and haplotypes. Further analysis stratified by etiology also showed no association. These results suggest that MTHFR polymorphisms play no significant role in susceptibility to ONFH in the Korean population.

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Authors and Affiliations

  1. Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu, 700-412, Korea

    Tae-Ho Kim, Jung Min Hong, Hyun-Ju Kim, Eui Kyun Park & Shin-Yoon Kim

  2. Department of Medicine, Kyungpook National University School of Medicine, Daegu, 700-422, Korea

    Tae-Ho Kim

  3. Department of Orthopedic Surgery, Kyungpook National University School of Medicine, Daegu, 700-422, Korea

    Shin-Yoon Kim

  4. Department of Pathology and Regenerative Medicine, School of Dentistry, Kyungpook National University, Daegu, 700-412, Korea

    Eui Kyun Park

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  1. Tae-Ho Kim
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  2. Jung Min Hong
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  3. Hyun-Ju Kim
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  4. Eui Kyun Park
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  5. Shin-Yoon Kim
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Correspondence to Eui Kyun Park or Shin-Yoon Kim.

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Kim, TH., Hong, J.M., Kim, HJ. et al. Lack of association of MTHFR gene polymorphisms with the risk of osteonecrosis of the femoral head in a Korean population. Mol Cells 29, 343–348 (2010). https://doi.org/10.1007/s10059-010-0054-7

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  • DOI: https://doi.org/10.1007/s10059-010-0054-7

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