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Fragile X mental retardation protein in learning-related synaptic plasticity

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Molecules and Cells

Abstract

Fragile X syndrome (FXS) is caused by a lack of the fragile X mental retardation protein (FMRP) due to silencing of the Fmr1 gene. As an RNA binding protein, FMRP is thought to contribute to synaptic plasticity by regulating plasticity-related protein synthesis and other signaling pathways. Previous studies have mostly focused on the roles of FMRP within the hippocampus - a key structure for spatial memory. However, recent studies indicate that FMRP may have a more general contribution to brain functions, including synaptic plasticity and modulation within the prefrontal cortex. In this brief review, we will focus on recent studies reported in the prefrontal cortex, including the anterior cingulate cortex (ACC). We hypothesize that alterations in ACC-related plasticity and synaptic modulation may contribute to various forms of cognitive deficits associated with FXS.

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  1. Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario, Canada, M5S 1A8

    Valentina Mercaldo, Giannina Descalzi & Min Zhuo

  2. Department of Brain and Cognitive Sciences, Seoul National University, Seoul, 151-746, Korea

    Min Zhuo

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  1. Valentina Mercaldo
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  2. Giannina Descalzi
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Correspondence to Min Zhuo.

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Mercaldo, V., Descalzi, G. & Zhuo, M. Fragile X mental retardation protein in learning-related synaptic plasticity. Mol Cells 28, 501–507 (2009). https://doi.org/10.1007/s10059-009-0193-x

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