ABSTRACT
A four-generation family with nine individuals with temporal partial epilepsy was studied. Detailed epilepsy history was investigated by structured interview. All putatively affected family members underwent a standardized electroencephalographic examination. The phenotype in the family was characterized by a short acoustic aura followed by rapid secondary generalization. To examine if the trait is linked to a region on 10q (interval D10S185–D10S1671), which has been reported in two other epilepsy families with similar phenotypes, linkage analysis was performed using nine markers covering the previously reported region. A maximum two-point LOD score of 2.1 at a recombination fraction of zero was obtained. All living affected individuals shared the same haplotype, while three unaffected at-risk adults did not. This result presents supporting evidence of a gene for partial epilepsy on 10q.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: February 28, 2000 / Accepted: March 28, 2000 / Published online: June 5, 2000
Rights and permissions
About this article
Cite this article
Mautner, VF., Lindenau, M., Gottesleben, A. et al. Supporting evidence of a gene for partial epilepsy on 10q. Neurogenetics 3, 31–34 (2000). https://doi.org/10.1007/s100480000091
Issue Date:
DOI: https://doi.org/10.1007/s100480000091