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References
Rosen DR, Bowling AC, Patterson D, Usdin TB, Sapp P, Mezey E, Kenna-Yasek D, O’Regan J, Rahmani Z, Ferrante RJ (1994) A frequent ala 4 to val superoxide dismutase-1 mutation is associated with a rapidly progressive familial amyotrophic lateral sclerosis. Hum Mol Genet 3(6):981–987
Rosen DR (2004) A shared chromosome-21 haplotype among amyotrophic lateral sclerosis families with the A4V SOD1 mutation. Clin Genet 66(3):247–250
Andersen PM, Forsgren L, Binzer M, Nilsson P, la-Hurula V, Keranen ML, Bergmark L, Saarinen A, Haltia T, Tarvainen I, Kinnunen E, Udd B, Marklund SL (1996) Autosomal recessive adult-onset amyotrophic lateral sclerosis associated with homozygosity for Asp90Ala CuZn-superoxide dismutase mutation. A clinical and genealogical study of 36 patients. Brain 119(4):1153–1172
Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, O’Connell P, Stern MP (1999) Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet 64(4):1127–1140
Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder, Penchaszadeh G, Roberts SA, Gayan J, Brocklebank D, Cherny SS, Cardon LR, GrayJ, Dlouhy SR, Wiktorski S, Hodes ME, Conneally PM, Penney JB, Gusella J, Cha JH, Irizarry M, Rosas D, Hersch S, Hollingsworth Z, MacDonald M, Young AB, Andresen JM, Housman DE, De Young MM, Bonilla E, Stillings T, Negrette A, Snodgrass SR, Martinez-Jaurrieta MD, Ramos-Arroyo MA, Bickham J, Ramos JS, Marshall F, Shoulson I, Rey GJ, Feigin A, Arnheim N, Acevedo-Cruz A, Acosta L, Alvir J, Fischbeck K, Thompson LM, Young A, Dure L, O’Brien CJ, Paulsen J, Brickman A, Krch D, Peery S, Hogarth P, Higgins DS Jr, Landwehrmeyer B, US–Venezuela Collaborative Research Project (2004) Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington’s disease age of onset. Proc Natl Acad Sci U S A 101(10):3498–3503
Li YJ, Scott WK, Hedges DJ, Zhang F, Gaskell PC, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Allen FA Jr, Goetz CG, Mastaglia F, Stajich JM, Gibson RA, Middleton LT, Saunders AM, Scott BL, Small GW, Nicodemus KK, Reed AD, Schmechel DE, Welsh-Bohmer KA, Conneally PM, Roses AD, Gilbert JR, Vance JM, Haines JL, Pericak-Vance MA (2002) Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet 70(4):985–993
Acknowledgment
We would like to express our appreciation to all of the families who generously participated in this study. This study was supported by a personal donation from Mr. Francesco Caleffi, Fontaneto D’Agogna, Novara, Italy, and from the Motor Neurone Disease Association (MNDA UK). AAC was funded by a Medical Research Council (UK) Clinician Scientist Fellowship. P.M.A. was funded by the Swedish Brain Research Foundation, the Hållstens Research Foundation, the Swedish Medical Society, and the Björklund Foundation for ALS Research, and the Swedish Association for the Neurologically Disabled. R.H.B. and D.M. receive support from the National Institutes of Health (NINDS, NIA), Project ALS, the ALS Association, the Muscular Dystrophy Association, the Al-Athel ALS Research Foundation, the Delaney Fund, and the ALS Therapy Alliance.
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Fogh, I., Rijsdijk, F., Andersen, P.M. et al. Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality. Neurogenetics 8, 235–236 (2007). https://doi.org/10.1007/s10048-007-0092-2
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DOI: https://doi.org/10.1007/s10048-007-0092-2