Skip to main content
Log in

Combination of ECMO and cytokine adsorption therapy for severe sepsis with cardiogenic shock and ARDS due to Panton–Valentine leukocidin—positive Staphylococcus aureus pneumonia and H1N1

  • Case Report
  • Artificial Lung / ECMO
  • Published:
Journal of Artificial Organs Aims and scope Submit manuscript

Abstract

Sepsis-induced cardiogenic shock in combination with severe acute respiratory failure represents a life-threatening combination that is often refractory to the conventional methods of treatment. We describe the case of a 33-year-old patient who developed acute cardiovascular collapse and ARDS secondary to superinfection of Panton–Valentine leukocidin—positive Staphylococcus aureus and H1N1 pneumonia who underwent successful combination therapy for severe sepsis-related cardiomyopathy and respiratory failure using extracorporeal membrane oxygenation and cytokine adsorption therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Gillet Y, Issartel B, Vanhems P, et al. Association between Staphylococcus aureus strains carrying gene for Panton–Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet. 2002;359:753–9.

    Article  CAS  PubMed  Google Scholar 

  2. Gauduchon V, Cozon G, Vandenesch F, et al. Neutralization of Staphylococcus aureus Panton–Valentine leukocidin by intravenous immunoglobulin in vitro. J Infect Dis. 2004;189:346–53.

    Article  CAS  PubMed  Google Scholar 

  3. Rouzic N, Janvier F, Libert N, et al. Prompt and successful toxin-targeting treatment of three patients with necrotizing pneumonia due to Staphylococcus aureus strains carrying the Panton–Valentine leukocidin genes. J Clin Microbiol. 2010;48:1952–5.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Morgan MS. Diagnosis and treatment of Panton–Valentine leukocidin (PVL)-associated staphylococcal pneumonia. Int J Antimicrob Agents. 2007;30:289–96.

    Article  CAS  PubMed  Google Scholar 

  5. Salliot C, Zeller V, Puechal X, et al. Panton–Valentine leukocidin-producing Staphylococcus aureus infections: report of 4 French cases. Scand J Infect Dis. 2006;38:192–5.

    Article  PubMed  Google Scholar 

  6. Noah MA, Dawrant M, Faulkner GM, et al. Panton–Valentine leukocidin expressing Staphylococcus aureus pneumonia managed with extracorporeal membrane oxygenation: experience and outcome. Crit Care Med. 2010;38:2250–3.

    Article  PubMed  Google Scholar 

  7. Fujisaki N, Takahashi A, Arima T, et al. Successful treatment of Panton–Valentine leukocidin-expressing Staphylococcus aureus-associated pneumonia co-infected with influenza using extracorporeal membrane oxygenation. In Vivo. 2014;28:961–5.

    PubMed  Google Scholar 

  8. Maclaren G, Butt W. Extracorporeal membrane oxygenation and sepsis. Critical care and resuscitation J Australas Acad Cri Care Med. 2007;9:76–80.

    Google Scholar 

  9. Brechot N, Luyt CE, Schmidt M, et al. Venoarterial extracorporeal membrane oxygenation support for refractory cardiovascular dysfunction during severe bacterial septic shock. Crit Care Med. 2013;41:1616–26.

    Article  CAS  PubMed  Google Scholar 

  10. Gabel E, Gudzenko V, Cruz D, et al. Successful use of extracorporeal membrane oxygenation in an adult patient with toxic shock-induced heart failure. J Intensive Care Med. 2015;30:115–8.

    Article  PubMed  Google Scholar 

  11. Nakada TA, Oda S, Matsuda K, et al. Continuous hemodiafiltration with PMMA hemofilter in the treatment of patients with septic shock. Mol Med. 2008;14:257–63.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Song M, Winchester J, Albright RL, et al. Cytokine removal with a novel adsorbent polymer. Blood Purif. 2004;22:428–34.

    Article  CAS  PubMed  Google Scholar 

  13. Morris C, Gray L, Giovannelli M. Early report: the use of Cytosorb haemoabsorption column as an adjunct in managing severe sepsis: initial experiences, review and recommendations. J Intensive Care Soc. 2015;16:257–64.

    Article  Google Scholar 

  14. Hetz H, Berger R, Recknagel P, et al. Septic shock secondary to beta-hemolytic streptococcus-induced necrotizing fasciitis treated with a novel cytokine adsorption therapy. Int J Artif Organs. 2014;37:422–6.

    Article  PubMed  Google Scholar 

  15. Basu R, Pathak S, Goyal J, et al. Use of a novel hemadsorption device for cytokine removal as adjuvant therapy in a patient with septic shock with multi-organ dysfunction: a case study. Indian J Crit Care Med. 2014;18:822–4.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Bruenger F, Kizner L, Weile J, et al. First successful combination of ECMO with cytokine removal therapy in cardiogenic septic shock: a case report. Int J Artif Organs. 2015;38:113–6.

    Article  CAS  PubMed  Google Scholar 

  17. Bracht H, Schneider EM, Weiss M, Hohmann H, Georgieff M, Barth E. Pattern of cytokine removal using an adsorption column CytoSorb during severe Candida albicans induced septic shock. Infection. 2013;41:S1–90.

    Google Scholar 

Download references

Acknowledgments

The Cytosorb device was purchased from Linc Medical, Leicestershire, UK; representatives of whom have also been involved in educating staff.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to NJ Lees or A Sabashnikov.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lees, N., Rosenberg, A., Hurtado-Doce, A. et al. Combination of ECMO and cytokine adsorption therapy for severe sepsis with cardiogenic shock and ARDS due to Panton–Valentine leukocidin—positive Staphylococcus aureus pneumonia and H1N1. J Artif Organs 19, 399–402 (2016). https://doi.org/10.1007/s10047-016-0915-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10047-016-0915-8

Keywords

Navigation