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Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology

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Abstract

Ideally, artificial bones should be dimensionally compatible with deformities, and be biodegradable and osteoconductive; however, there are no artificial bones developed to date that satisfy these requirements. We fabricated novel custom-made artificial bones from α-tricalcium phosphate powder using an inkjet printer and implanted them in ten patients with maxillofacial deformities. The artificial bones had dimensional compatibility in all the patients. The operation time was reduced due to minimal need for size adjustment and fixing manipulation. The postsurgical computed tomography analysis detected partial union between the artificial bones and host bone tissues. There were no serious adverse reactions. These findings provide support for further clinical studies of the inkjet-printed custom-made artificial bones.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    Hideto Saijo, Kazuyo Igawa, Yuki Kanno, Yoshiyuki Mori, Kayoko Kondo, Daichi Chikazu, Mitsuki Iino & Tsuyoshi Takato

  2. Division of Tissue Engineering, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Ung-il Chung

  3. Biomechanics Development Center, Next21 K.K., Tokyo, Japan

    Koutaro Shimizu & Shigeki Suzuki

  4. Advanced Development and Supporting Center, RIKEN, Saitama, Japan

    Masahiro Anzai

  5. Laboratory of Veterinary Surgery, Faculty of Agriculture, University of Tokyo, Tokyo, Japan

    Nobuo Sasaki

Authors
  1. Hideto Saijo
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  2. Kazuyo Igawa
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  3. Yuki Kanno
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  4. Yoshiyuki Mori
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  5. Kayoko Kondo
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  6. Koutaro Shimizu
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  7. Shigeki Suzuki
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  8. Daichi Chikazu
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  9. Mitsuki Iino
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  10. Masahiro Anzai
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  11. Nobuo Sasaki
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  12. Ung-il Chung
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  13. Tsuyoshi Takato
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Corresponding author

Correspondence to Ung-il Chung.

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Saijo, H., Igawa, K., Kanno, Y. et al. Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology. J Artif Organs 12, 200–205 (2009). https://doi.org/10.1007/s10047-009-0462-7

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  • DOI: https://doi.org/10.1007/s10047-009-0462-7

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