Abstract
In order to investigate the effects of anatomical variation in human heads on the optical mapping of brain activity, we perform simulations of optical mapping by solving the photon diffusion equation for layered-models simulating human heads using the finite element method (FEM). Particularly, the effects of the spatial variations in the thicknesses of the skull and cerebrospinal fluid (CSF) layers on mapping images are investigated. Mapping images of single active regions in the gray matter layer are affected by the spatial variations in the skull and CSF layer thicknesses, although the effects are smaller than those of the positions of the active region relative to the data points. The increase in the skull thickness decreases the sensitivity of the images to active regions, while the increase in the CSF layer thickness increases the sensitivity in general. The images of multiple active regions are also influenced by their positions relative to the data points and by their depths from the skin surface.
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A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, and H. Koizumi: Med. Phys. 22 (1995) 1997.
Y. Yamashita, A. Maki, and H. Koizumi: J. Biomed. Opt. 4 (1999) 414.
A. Villringer and B. Chance: Trends Neurosci. 20 (1997) 435.
Y. Hoshi: Psychophysiology 40 (2003) 511.
M. Firbank, S. R. Arridge, M. Schweiger, and D. T. Delpy: Phys. Med. Biol. 41 (1996) 767.
H. Dehghani and D. T. Delpy: Appl. Opt. 39 (2000) 4721.
E. Okada and D. T. Delpy: Appl. Opt. 42 (2003) 2906.
N. Chauveau, X. Franceries, B. Doyon, B. Rigaud, J. P. Morucci, and P. Celsis: Hum. Brain Mapp. 21 (2004) 86.
Y. Yamada and Y. Hasegawa: JSME Int. J., Ser. B 39 (1996) 754.
E. Okada and D. T. Delpy: Appl. Opt. 42 (2003) 2915.
Y. Fukui, Y. Ajichi, and E. Okada: Appl. Opt. 42 (2003) 2881.
M. Firbank, E. Okada, and D. T. Delpy: NeuroImage 8 (1998) 69.
H. Kawaguchi, T. Hayashi, T. Kato, and E. Okada: Phys. Med. Biol. 49 (2004) 2753.
D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, and J. Wyatt: Phys. Med. Biol. 33 (1988) 1433.
D. T. Sandwell: Geophys. Res. Lett. 14 (1987) 139.
T. Koyama, A. Iwasaki, Y. Ogoshi, and E. Okada: Appl. Opt. 44 (2005) 2094.
H. Zhao, Y. Tanikawa, F. Gao, Y. Onodera, A. Sassaroli, K. Tanaka, and Y. Yamada: Phys. Med. Biol. 47 (2002) 2075.
W. F. Cheong, S. A. Prahl, and A. J. Welch: IEEE J. Quantum Electron. 26 (1990) 2166.
T. Yamamoto, A. Maki, T. Kadoya, Y. Tanikawa, Y. Yamada, E. Okada, and H. Koizumi: Phys. Med. Biol. 47 (2002) 3429.
B. C. Wilson and G. Adam: Med. Phys. 10 (1983) 824.
J. J. Duderstadt and L. J. Hamilton: Nuclear Reactor Analysis (Wiley, New York, 1976) Chap. 4.
A. Ishimaru: Wave Propagation and Scattering in Random Media (Academic Press, New York, 1978) Vol. 1.
Y. Yamada: in Annual Review of Heat Transfer, ed. C.-L. Tien (Begell House, New York, 1995) Vol. VI, p. 1.
K. Furutsu and Y. Yamada: Phys. Rev. E 50 (1994) 3634.
R. A. J. Groenhuis, H. A. Ferwerda, and J. J. Ten Bosch: Appl. Opt. 22 (1983) 2456.
J. Haselgrove, J. Leigh, C. Yee, N. G. Wang, M. Maris, and B. Chance: Proc. SPIE 1431 (1991) 30.
T. J. Farrell, M. S. Patterson, and B. Wilson: Med. Phys. 19 (1992) 879.
S. Takahashi and Y. Yamada: Advances in Optical Imaging and Photon Migration (AOIPM) 1998 (Optical Society of America, Washington, D.C., 1998) OSA Trends in Optics and Photonics (TOPS) Vol. 21, p. 2.
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Wang, S., Shibahara, N., Kuramashi, D. et al. Effects of spatial variation of skull and cerebrospinal fluid layers on optical mapping of brain activities. OPT REV 17, 410–420 (2010). https://doi.org/10.1007/s10043-010-0076-6
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DOI: https://doi.org/10.1007/s10043-010-0076-6