Abstract.
We screened DNAs of 48 Japanese individuals for single-nucleotide polymorphisms (SNPs) in six genes encoding proteins of the solute carrier (SLC) family by direct sequencing of their entire genomic regions except for repetitive-sequence elements. This approach identified 213 SNPs and 25 insertion/deletion polymorphisms among the six genes. On average, we identified 1 SNP in every 509 nucleotides. Of the 213 SNPs, 14 were identified in the SLC10A1 gene, 51 in SLC15A1, 29 in SLC22A1, 27 in SLC22A2, 54 in SLC22A4, and 38 in SLC22A5. Eight were located in 5′ flanking regions, 172 in introns, 25 in exons, and 8 in 3′ flanking regions. These variants should contribute to investigations of possible correlations between genotypes and phenotypes as regards disease susceptibilities or responsiveness to drug therapy.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Additional information
Received: July 24, 2002 / Accepted: July 25, 2002
Correspondence to:Y. Nakamura
Rights and permissions
About this article
Cite this article
Saito, S., Iida, A., Sekine, A. et al. Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population. J Hum Genet 47, 576–584 (2002). https://doi.org/10.1007/s100380200088
Published:
Issue Date:
DOI: https://doi.org/10.1007/s100380200088
This article is cited by
-
Structural basis of hepatitis B virus receptor binding
Nature Structural & Molecular Biology (2024)
-
Structure of the bile acid transporter and HBV receptor NTCP
Nature (2022)
-
Effect of S267F variant of NTCP on the patients with chronic hepatitis B
Scientific Reports (2017)
-
Di- and tripeptide transport in vertebrates: the contribution of teleost fish models
Journal of Comparative Physiology B (2017)
-
Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1
Genome Medicine (2015)