Abstract
Tumor necrosis factor alpha (TNFα) in activated monocytes exerts cytotoxic activity and has a variety of other biological effects. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the gene located at 6p21.3. High heterozygosity (0.80) makes this polymorphism a useful marker in the genetic study of disorders affecting immunological response and cell differentiation.
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Received: June 2, 1998 / Accepted: June 24, 1998
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Tsukamoto, K., Ohta, N., Shirai, Y. et al. A highly polymorphic CA repeat marker at the human tumor necrosis factor alpha (TNFAα) locus. J Hum Genet 43, 278–279 (1998). https://doi.org/10.1007/s100380050090
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DOI: https://doi.org/10.1007/s100380050090
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