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The influence of porosity on the integration histology of two polypropylene meshes for the treatment of abdominal wall defects in dogs

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Abstract

Two types of monofilament polypropylene mesh with different pore sizes, mass densities and burst strengths were used to repair two identical paired full-thickness abdominal wall defects in ten dogs, in order to compare their integration histology 90 days after implantation. On one side a standard mesh, Prolene® (Ethicon), was sutured to the borders of the defect, while on the other a new ultralightweight macroporous mesh, Mpathy® mesh, was used. There was a significantly greater densitometric proportion of mature (type I) collagen (58.38%) for Mpathy® mesh compared to Prolene® (34.05%, P = 0.01). Although Prolene® has 3.6 times the burst strength of Mpathy® mesh, the implanted tissue strength was marginally greater for Mpathy® mesh. We conclude that Mpathy® mesh gives a surgical repair that is at least as strong as that provided by Prolene®, along with a higher concentration of mature collagen and less fibrosis (P = 0.07), in this canine histology model.

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Authors and Affiliations

  1. Experimental Surgery Department, Pontifical Catholic University of Paraná, Paraná, Brazil

    F. H. Greca, Z. A. Souza-Filho, A. Giovanini, M. R. Rubin, R. F. Kuenzer, F. B. Reese & L. M. Araujo

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  1. F. H. Greca
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  2. Z. A. Souza-Filho
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  3. A. Giovanini
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  4. M. R. Rubin
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  5. R. F. Kuenzer
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  6. F. B. Reese
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  7. L. M. Araujo
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Correspondence to F. H. Greca.

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Greca, F.H., Souza-Filho, Z.A., Giovanini, A. et al. The influence of porosity on the integration histology of two polypropylene meshes for the treatment of abdominal wall defects in dogs. Hernia 12, 45–49 (2008). https://doi.org/10.1007/s10029-007-0276-6

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  • DOI: https://doi.org/10.1007/s10029-007-0276-6

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