Abstract
While polypropylene mesh remains the preferred prosthesis material for hernioplasties, there are some problems with infections, intestinal obstruction and fistulization, and migration particularly in immunodepressed patients. A new degradable and reabsorbable material, the porcine small intestinal submucosa (Surgisis) has been developed for hernia repairs in humans. This prospective study evaluated the safety and efficacy of Lichtenstein hernioplasty using the Surgisis inguinal hernia matrix soft-tissue graft as a mesh in ten immunodepressed subjects. Six subjects were HIV-positive in the immunodepressive phase, and the other four had undergone transplantation (three kidney, one liver). There were no intraoperative or postoperative complications, recurrences, or wound infections. Thus Lichtenstein’s hernioplasty using the Surgisis inguinal hernia matrix soft-tissue graft in immunodepressed patients promises safety and efficacy.
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Jones S, Schechter CB, Smith C, Rose DN (2002) Is HIV infection a risk factor for complications of surgery? Mt Sinai J Med 69:329–333
Amid PK (2003) The Lichtenstein repair in 2002: an overview of causes of recurrence after Lichtenstein tension-free hernioplasty. Hernia 7:13–16
Dunne JR, Malone DL, Tracy JK, Napolitano LM (2003) Abdominal wall hernias: risk factors for infection and resource utilization. J Surg Res 111:78–84
Ansaloni L, Catena F, D’Alessandro L (2004) Prospective randomized, double-blind, controlled trial comparing Lichtenstein’s repair of inguinal hernia with polypropylene mesh versus Surgisis gold soft tissue graft: preliminary results. Acta Biomed Ateneo Parmense 74:26–29
Kaufman Z, Engelberg M, Zager M (1981) Fecal fistula: a late complication of Marlex mesh repair. Dis Colon Rectum 24:543–4
Badylak S, Arnoczky S, Plouhar P, Haut R, Mendenhall V, Clarke R, Horvath C (1999) Naturally occurring extracellular matrix as a scaffold for musculoskeletal repair. Clin Orthop 367: S333–43
DeBord JR, Bauer JJ, Grischkan DM, LeBlanc KA, Smoot RT Jr, Voeller GR, Weiland LH (1999) Short-term study on the safety of antimicrobial-agent-impregnated ePTFE patches for hernia repair Hernia 3:189–193
Rodier JF (1999) Concerning “intraperitoneal polyglactin 910 absorbable prosthesis: a risk-free preventive method?” Ann Chir 53:1054–1055
Hodde JP, Record RD, Tullius RS, Badylak SF (2002) Retention of endothelial cell adherence to porcine-derived extracellular matrix after disinfection and sterilization. Tissue Eng 8:225–234
Hodde J, Record R, Tullius R, Badylak S (2002) Fibronectin peptides mediate HMEC adhesion to porcine-derived extracellular matrix. Biomaterials 23:1841–1848
Allman AJ, McPherson TB, Badylak SF, Merrill LC, Kallakury B, Sheehan C, Raeder RH, Metzger DW (2001) Xenogeneic extracellular matrix grafts elicit a TH2-restricted immune response. Transplantation 71:1631–1640
Record RD, Hillegonds D, Simmons C, Tullius R, Rickey FA, Elmore D, Badylak SF (2001) In vivo degradation of 14C-labeled small intestinal submucosa (SIS) when used for urinary bladder repair. Biomaterials 22:2653–2659
Badylak S, Kokini K, Tullius B, Simmons-Byrd A, Morff R (2002) Morphologic study of small intestinal submucosa as a body wall repair device. J Surg Res 103:190–202
Badylak S, Arnoczky S, Plouhar P, Haut R, Mendenhall V, Clarke R, Horvath C (1999) Naturally occurring extracellular matrix as a scaffold for musculoskeletal repair. Clin Orthop 367: S333–43
Welch JA, Montgomery RD, Lenz SD, Plouhar P, Shelton WR (2002) Evaluation of small-intestinal submucosa implants for repair of meniscal defects in dogs. Am J Vet Res 63:427–431
Knoll LD (2002) Use of porcine small intestinal submucosal graft in the surgical management of tunical deficiencies with penile prosthetic surgery. Urology 59:758–761
Jaffe JS, Ginsberg PC, Yanoshak SJ, Costa LE Jr, Ogbolu FN, Moyer CP, Greene CH, Finkelstein LH, Harkaway RC (2001) Ureteral segment replacement using a circumferential small-intestinal submucosa xenogenic graft. J Invest Surg 14:259–265
Sofer M, Rowe E, Forder DM, Denstedt JD (2002) Ureteral segmental replacement using multilayer porcine small-intestinal submucosa. J Endourol 16:27–31
Grossklaus DJ, Shappell SB, Adams MC, Brock JW 3rd, Pope JC 4th (2001) Small intestinal submucosa as a urethral coverage layer. J Urol 166:636–639
Kini S, Gagner M, de Csepel J, Gentileschi P, Dakin G (2001) A biodegradeable membrane from porcine intestinal submucosa to reinforce the gastrojejunostomy in laparoscopic Roux-en-Y gastric bypass: preliminary report. Obes Surg 11:469–473
Chen MK, Badylak SF (2001) Small bowel tissue engineering using small intestinal submucosa as a scaffold. J Surg Res 99:352–358
Lantz GC, Badylak SF, Coffey AC, Geddes LA, Sandusky GE (1992) Small intestinal submucosa as a superior vena cava graft in the dog. J Surg Res 53:175–181
Lantz GC, Badylak SF, Coffey AC, Geddes LA, Blevins WE (1990) Small intestinal submucosa as a small-diameter arterial graft in the dog. J Invest Surg 3:217–227
Hiles MC, Badylak SF, Lantz GC, Kokini K, Geddes LA, Morff RJ (1995) Mechanical properties of xenogeneic small-intestinal submucosa when used as an aortic graft in the dog. J Biomed Mater Res 29:883–891
Marshall SE, Tweedt SM, Greene CH, Ballestas LY, Bunning KR, Costa LE, Harrison TD, Higgins CM, Hoertz MJ, Hollobaugh DA, Jaffe JS, Koenig GJ, Lewbart MB, Liccini MS, Lopez CS, Lynch GS, Marshall JO, Mazzoni JA, Moeller JP, Raab DC, Reap JC, Selgrath CE, Sweitzer LM, Valentino DJ, Vota SA (2000) An alternative to synthetic aortic grafts using jejunum. J Invest Surg 13:333–341
Clarke KM, Lantz GC, Salisbury SK, 28) Clarke KM, Lantz GC, Salisbury SK, Badylak SF, Hiles MC, Voytik SL (1996) Intestine submucosa and polypropylene mesh for abdominal wall repair in dogs. J Surg Res 60:107–114
Badylak S, Kokini K, Tullius B, Whitson B (2001) Strength over time of a resorbable bioscaffold for body wall repair in a dog model. J Surg Res 99:282–187
Franklin ME, Gonzalez JJ, Michaelson RP, Glass JL, Chock DA (2002) Preliminary experience with new bioactive prosthetic material for repair of hernias in infected fields. Hernia 6:171–174
Acknowledgements
This research was presented at the Seventh Annual Scientific Meeting of the American Hernia Society, Orlando, Fla., 24–28 February 2004.
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Catena, F., Ansaloni, L., Leone, A. et al. Lichtenstein repair of inguinal hernia with Surgisis inguinal hernia matrix soft-tissue graft in immunodepressed patients. Hernia 9, 29–31 (2005). https://doi.org/10.1007/s10029-004-0273-y
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DOI: https://doi.org/10.1007/s10029-004-0273-y