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Sudden, Unexpected Death Associated with Meningioangiomatosis: Case Report

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Pediatric and Developmental Pathology

Abstract

We report a case of sudden, unexpected death associated with meningioangiomatosis in a 13-year-old, previously healthy male without a history of seizures, neurologic deficits, or clinical stigmata of neurofibromatosis. There was no family history of neurofibromatosis. The postmortem examination showed a 5-cm mass involving the right posterior frontal and orbital frontal cortex that had microscopic features diagnostic of meningioangiomatosis. Because no other cause of death was found, we postulate that he likely died as a result of a seizure secondary to meningioangiomatosis.

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References

  1. P Hartmann A Ramseier F Gudat et al. (1994) ArticleTitle[Normal weight of the brain in adults in relation to age, sex, body height and weight] Pathologe 15 165–170 Occurrence Handle10.1007/s002920050040 Occurrence Handle1:STN:280:DyaK2czlt1yktg%3D%3D Occurrence Handle8072950

    Article  CAS  PubMed  Google Scholar 

  2. S Wiebe DG Munoz S Smith DH Lee (1999) ArticleTitleMeningioangiomatosis. A comprehensive analysis of clinical and laboratory features Brain 122 IssueIDpt 4 709–726 Occurrence Handle10.1093/brain/122.4.709 Occurrence Handle10219783

    Article  PubMed  Google Scholar 

  3. A Chakrabarty AJ Franks (1999) ArticleTitleMeningioangiomatosis: a case report and review of the literature Br J Neurosurg 13 167–173 Occurrence Handle10.1080/02688699943385 Occurrence Handle1:STN:280:DC%2BD3c%2Fotl2muw%3D%3D Occurrence Handle10616586

    Article  CAS  PubMed  Google Scholar 

  4. K Fujimoto Y Nikaidoh T Yuasa et al. (1993) ArticleTitleMeningioangiomatosis not associated with von Recklinghausen’s disease—case report Neurol Med Chir (Tokyo) 33 651–655 Occurrence Handle1:STN:280:DyaK2c%2FovVyjsQ%3D%3D Occurrence Handle10.2176/nmc.33.651

    Article  CAS  Google Scholar 

  5. PC Burger BW Scheithauer FS Vogel (2002) Surgical Pathology of the Nervous System and Its Coverings Churchill Livingstone New York

    Google Scholar 

  6. J Halper BW Scheithauer H Okazaki ER Laws SuffixJr (1986) ArticleTitleMeningio-angiomatosis: a report of six cases with special reference to the occurrence of neurofibrillary tangles J Neuropathol Exp Neurol 45 426–446 Occurrence Handle1:STN:280:DyaL283ltlantg%3D%3D Occurrence Handle3088216

    CAS  PubMed  Google Scholar 

  7. NR Kim G Choe SH Shin et al. (2002) ArticleTitleChildhood meningiomas associated with meningioangiomatosis: report of five cases and literature review Neuropathol Appl Neurobiol. Feb 28 48–56 Occurrence Handle10.1046/j.1365-2990.2002.00365.x Occurrence Handle1:STN:280:DC%2BD387hslOjtg%3D%3D

    Article  CAS  Google Scholar 

  8. S Meyer B Romeike M Strowitzki et al. (2002) ArticleTitle[Meningioangiomatosis with associated meningioma in a 4-year-old girl presenting with a focal seizure] Nervenarzt 73 990–994 Occurrence Handle10.1007/s00115-002-1356-6 Occurrence Handle1:STN:280:DC%2BD38nhvFekug%3D%3D Occurrence Handle12376888

    Article  CAS  PubMed  Google Scholar 

  9. P Sinkre A Perry D Cai et al. (2001) ArticleTitleDeletion of the NF2 region in both meningioma and juxtaposed meningioangiomatosis: case report supporting a neoplastic relationship Pediatr Dev Pathol 4 568–572 Occurrence Handle10.1007/s10024001-0086-2 Occurrence Handle1:STN:280:DC%2BD38%2FpsVersA%3D%3D Occurrence Handle11826364

    Article  CAS  PubMed  Google Scholar 

  10. F Giangaspero A Guiducci FA Lenz et al. (1999) ArticleTitleMeningioma with meningioangiomatosis: a condition mimicking invasive meningiomas in children and young adults: report of two cases and review of the literature Am J Surg Pathol 23 872–875 Occurrence Handle10.1097/00000478-199908000-00002 Occurrence Handle1:STN:280:DyaK1MzmtF2jtQ%3D%3D Occurrence Handle10435554

    Article  CAS  PubMed  Google Scholar 

  11. Y Takeshima VJ Amatya F Nakayori et al. (2002) ArticleTitleMeningioangiomatosis occurring in a young male without neurofibromatosis: with special reference to its histogenesis and loss of heterozygosity in the NF2 gene region Am J Surg Pathol 26 125–129 Occurrence Handle10.1097/00000478-200201000-00017 Occurrence Handle11756780

    Article  PubMed  Google Scholar 

  12. E Izycka-Swieszewska R Rzepko S Kopczynski et al. (2000) ArticleTitleMeningioangiomatosis with a predominant fibrocalcifying component Neuropathology 20 44–48 Occurrence Handle10.1046/j.1440-1789.2000.00278.x Occurrence Handle1:STN:280:DC%2BD3cvhvFOjsQ%3D%3D Occurrence Handle10935436

    Article  CAS  PubMed  Google Scholar 

  13. GW Jay JE Leestma (1981) ArticleTitleSudden death in epilepsy. A comprehensive review of the literature and proposed mechanisms Acta Neurol Scand Suppl 82 1–66 Occurrence Handle1:STN:280:DyaL38%2FitVegtg%3D%3D Occurrence Handle7025550

    CAS  PubMed  Google Scholar 

  14. RH Rhodes RL Davis (1978) ArticleTitleAn unusual fibro-osseous component in intracranial lesions Hum Pathol 9 309–319 Occurrence Handle1:STN:280:DyaE1c7pt1yhsQ%3D%3D Occurrence Handle658964

    CAS  PubMed  Google Scholar 

  15. JI Lopez C Ereno L Oleaga E Areitio (1996) ArticleTitleMeningioangiomatosis and oligodendroglioma in a 15-year-old boy Arch Pathol Lab Med 120 587–590 Occurrence Handle1:STN:280:DyaK283lsFGrug%3D%3D Occurrence Handle8651864

    CAS  PubMed  Google Scholar 

  16. P Savargaonkar S Chen T Bhuiya et al. (2003) ArticleTitleMeningioangiomatosis: report of three cases and review of the literature Ann Clin Lab Sci 33 115–118 Occurrence Handle12661908

    PubMed  Google Scholar 

  17. SM Huson PS Harper DA Compston (1988) ArticleTitleVon Recklinghausen neurofibromatosis. A clinical and population study in south-east Wales Brain 111 IssueIDpt 6 1355–1381 Occurrence Handle3145091

    PubMed  Google Scholar 

  18. I Feigin (1971) ArticleTitleThe nerve sheath tumor, solitary and in von Recklinghausen’s disease; a unitary mesenchymal concept Acta Neuropathol (Berl) 17 188–200 Occurrence Handle10.1007/BF00685053 Occurrence Handle1:STN:280:DyaE3M7lvVygsQ%3D%3D

    Article  CAS  Google Scholar 

  19. SM DiMaio VJ DiMaio JB Kirkpatrick (1980) ArticleTitleSudden, unexpected deaths due to primary intracranial neoplasms Am J Forensic Med Pathol 1 29–45 Occurrence Handle1:STN:280:DyaL3M3gsVejsA%3D%3D Occurrence Handle6263083 Occurrence Handle10.1097/00000433-198003000-00007

    Article  CAS  PubMed  Google Scholar 

  20. RW Huntington SuffixJr KL Cummings TI Moe et al. (1965) ArticleTitleDiscovery of fatal primary intracranial neoplasms at medicolegal autopsies Cancer 18 117–127 Occurrence Handle14260073

    PubMed  Google Scholar 

  21. JE Leestma T Walczak JR Hughes et al. (1989) ArticleTitleA prospective study on sudden unexpected death in epilepsy Ann Neurol 26 195–203 Occurrence Handle10.1002/ana.410260203 Occurrence Handle1:STN:280:DyaL1Mznt1Oluw%3D%3D Occurrence Handle2774506

    Article  CAS  PubMed  Google Scholar 

  22. R Hunter W Blackwood J Bull (1968) ArticleTitleThree cases of frontal meningiomas presenting psychiatrically Br Med J 6 3 IssueID609 9–16 Occurrence Handle1:STN:280:DyaF1czisFyqtw%3D%3D Occurrence Handle10.1136/bmj.3.5609.9

    Article  CAS  Google Scholar 

  23. CF Lindboe KB Svenes L Slordal (1997) ArticleTitleSudden, unexpected death in subjects with undiagnosed gliomas Am J Forensic Med Pathol 18 271–275 Occurrence Handle10.1097/00000433-199709000-00008 Occurrence Handle1:STN:280:DyaK2svjs1ajtQ%3D%3D Occurrence Handle9290874

    Article  CAS  PubMed  Google Scholar 

  24. V Gross-Tsur O Manor J Meere Particlevan der et al. (1997) ArticleTitleEpilepsy and attention deficit hyperactivity disorder: is methylphenidate safe and effective? J Pediatr 130 670–674 Occurrence Handle1:STN:280:DyaK1c%2Fpt1Slug%3D%3D Occurrence Handle9432523

    CAS  PubMed  Google Scholar 

  25. H Feldman P Crumrine BL Handen et al. (1989) ArticleTitleMethylphenidate in children with seizures and attention-deficit disorder Am J Dis Child 143 1081–1086 Occurrence Handle1:STN:280:DyaL1MzntFKlsg%3D%3D Occurrence Handle2672786

    CAS  PubMed  Google Scholar 

  26. V Gross-Tsur RS Shalev N Badihi O Manor (2002) ArticleTitleEfficacy of methylphenidate in patients with cerebral palsy and attention-deficit hyperactivity disorder (ADHD) J Child Neurol 17 863–866 Occurrence Handle12593456

    PubMed  Google Scholar 

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Acknowledgments

We thank the CJ Foundation for SIDS and First Candle/SIDS Alliance for providing grant support for this study. We also thank the San Diego Guild for Infant Survival, the Guild for Infant Survival of Orange County, and the many families and friends of children who have died suddenly and unexpectedly and have contributed so generously to the San Diego SIDS/SUDC Research Project.

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Authors and Affiliations

  1. Children’s Hospital and Health Center, 3020 Children’s Way, MC5007, San Diego, CA, 92123, USA

    Chris Wixom, Amy E. Chadwick & Henry F. Krous

  2. University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA, 92093, USA

    Chris Wixom & Henry F. Krous

Authors
  1. Chris Wixom
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  2. Amy E. Chadwick
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  3. Henry F. Krous
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Correspondence to Henry F. Krous.

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Wixom, C., Chadwick, A.E. & Krous, H.F. Sudden, Unexpected Death Associated with Meningioangiomatosis: Case Report. Pediatr Dev Pathol 8, 240–244 (2005). https://doi.org/10.1007/s10024-004-9105-4

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  • DOI: https://doi.org/10.1007/s10024-004-9105-4

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