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Acute Lymphoblastic Leukemia with Hypereosinophilia: Report of a Case with 5q Deletion and Review of the Literature

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Pediatric and Developmental Pathology

Abstract

Peripheral blood eosinophilia as a presentation of acute lymphoblastic leukemia (ALL) has only rarely been reported. The eosinophilia is thought to be a nonneoplastic reaction to the neoplastic lymphoblasts. We present the case of a 5-year-old girl who developed peripheral hypereosinophilia with no circulating blasts prior to her diagnosis of B-cell lineage ALL. Cytogenetic study showed a hyperdiploid blast population with 5q deletion. Persistent peripheral hypereosinophilia should always be fully investigated, the possibility of a malignancy including ALL needs to be excluded, even in the absence of peripheral cytopenias and circulating blasts.

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Authors and Affiliations

  1. Section of Hematology/Oncology, Columbus Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USA, USA

    Tung T. Wynn & Mark Ranalli

  2. Department of Pathology, Division of Cytogenetics, Ohio State University, 167 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA

    Nyla A. Heerema

  3. Department of Laboratory Medicine, Columbus Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USA

    Sue Hammond & Samir B. Kahwash

Authors
  1. Tung T. Wynn
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  2. Nyla A. Heerema
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  3. Sue Hammond
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  4. Mark Ranalli
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  5. Samir B. Kahwash
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Corresponding author

Correspondence to Samir B. Kahwash.

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Wynn, T., Heerema, N., Hammond, S. et al. Acute Lymphoblastic Leukemia with Hypereosinophilia: Report of a Case with 5q Deletion and Review of the Literature. Pediatr. Dev. Pathol. 6, 558–563 (2003). https://doi.org/10.1007/s10024-003-2019-8

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  • DOI: https://doi.org/10.1007/s10024-003-2019-8

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