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Congenital Fibrosarcoma with Metastasis in a Fetus

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Pediatric and Developmental Pathology

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Abstract

It is well known that congenital or infantile fibrosarcoma has a much less aggressive behavior than fibrosarcoma in adults, and it rarely metastasizes. We report a case of congenital fibrosarcoma in a 26-wk-old fetus, the diagnosis of which was made by an in utero needle core biopsy. Metastatic tumors were identified at autopsy when the pregnancy was terminated 3 wk later. English literature of metastatic congenital fibrosarcoma was also reviewed.

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Acknowledgments

The authors thank Poul H.B. Sorensen, M.D., Ph.D, for performing RT-PCR for ETV6-NTRK3 at the Department of Pathology and Laboratory Medicine, Children’s and Women’s Health Centre of British Columbia, Vancouver, BC, Canada. The prenatal needle biopsy was reviewed by Dr. Cheryl Coffin at the Department of Pathology, Primary Children’s Medical Center, Salt Lake City, UT.

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Authors and Affiliations

  1. Department of Pathology, University of Maryland School of Medicine, 22 S. Greene Street, Baltimore, MD, 21201, USA

    Daisuke Nonaka & Chen-Chih J. Sun

  2. Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA

    Chen-Chih J. Sun

Authors
  1. Daisuke Nonaka
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  2. Chen-Chih J. Sun
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Correspondence to Chen-Chih J. Sun.

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Nonaka, D., Sun, CC. Congenital Fibrosarcoma with Metastasis in a Fetus. Pediatr. Dev. Pathol. 7, 187–191 (2004). https://doi.org/10.1007/s10024-003-0108-3

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  • DOI: https://doi.org/10.1007/s10024-003-0108-3

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