Abstract
This report describes a case of severe coagulopathy and bleeding related to the intraoperative use of topically applied thrombin. Commercial thrombin preparations contaminated with bovine factor V have been shown to stimulate the production of antibodies directed against factor V. These antibodies can cause coagulopathy. Our patient developed antibodies against factor V after intraoperative exposure to topical thrombin. The resulting antibody-mediated depletion of factor V caused a severe and refractory coagulopathy. Vascular surgeons should be aware that the use of topical bovine thrombin can cause severe coagulopathy.
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Sarfati, M.R., DiLorenzo, D.J., Kraiss, L.W. et al. Severe Coagulopathy following Intraoperative Use of Topical Thrombin. Ann Vasc Surg 18, 349–351 (2004). https://doi.org/10.1007/s10016-004-0028-3
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DOI: https://doi.org/10.1007/s10016-004-0028-3