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Whole-exome sequencing of a meningeal melanocytic tumour reveals activating CYSLTR2 and EIF1AX hotspot mutations and similarities to uveal melanoma

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Fig. 1
Fig. 2

Abbreviations

UM:

Uveal melanoma

CM:

Cutaneous melanoma

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Acknowledgements

We would like to thank the patient for allowing us to undertake these analyses and to share these data. We thank Dr. J. Koten for critically revising the manuscript. We are grateful to Marcel Jeunink for the assistance with the molecular analyses.

Funding

This work was supported by Cancer Research UK and the Wellcome Trust.

Author information

Author notes

  1. Heidi V. N. Küsters-Vandevelde and Menno R. Germans contributed equally to this work.

Authors and Affiliations

  1. Department of Pathology, Canisius Wilhelmina Hospital, P.O. Box 9015, 6500 GS, Nijmegen, The Netherlands

    Heidi V. N. Küsters-Vandevelde & Clemens F. M. Prinsen

  2. Department of Neurosurgery, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Menno R. Germans

  3. Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK

    Roy Rabbie, Mamunur Rashid & David J. Adams

  4. Department of Pathology, Radboud University Medical Center, P.O. Box 9101, IPC 842, 6500 HB, Nijmegen, The Netherlands

    Roel Ten Broek & Willeke A. M. Blokx

  5. Department of Neurosurgery, Radboud University Medical Center, P.O. Box 9101, IPC 633, 6500 HB, Nijmegen, The Netherlands

    Mark Ter Laan

Authors
  1. Heidi V. N. Küsters-Vandevelde
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  2. Menno R. Germans
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  3. Roy Rabbie
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  4. Mamunur Rashid
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  5. Roel Ten Broek
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  6. Willeke A. M. Blokx
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  7. Clemens F. M. Prinsen
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  8. David J. Adams
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  9. Mark Ter Laan
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Contributions

HK, MG, and ML designed the study, made substantial contributions to the acquisition and interpretation of data and wrote the manuscript. RR and DJA made substantial contributions to the acquisition and interpretation of molecular data, and were major contributors in writing the manuscript. MR, RB, CP, and WB contributed to the acquisition and interpretation of molecular data and WB and HK reviewed the histology. All authors were involved in drafting the manuscript or in its critical revisions, and participated sufficiently to take public responsibility for appropriate portions of the content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Heidi V. N. Küsters-Vandevelde.

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Conflict of interest

The authors report no conflicts of interest.

Ethical approval and consent to participate

Ethical approval was sought from the Commisie Mensgebonden Onderzoek, Nijmegen, Netherlands (CMO, ref.nr/Dossiernummer: 2016–2863). Written informed consent was obtained from the patient for publication of this case report and its accompanying images. A copy of the written consent is available for review by the editor.

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Küsters-Vandevelde, H.V.N., Germans, M.R., Rabbie, R. et al. Whole-exome sequencing of a meningeal melanocytic tumour reveals activating CYSLTR2 and EIF1AX hotspot mutations and similarities to uveal melanoma. Brain Tumor Pathol 35, 127–130 (2018). https://doi.org/10.1007/s10014-018-0308-1

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  • DOI: https://doi.org/10.1007/s10014-018-0308-1

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