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Diamond paste-based electrodes for the determination of sildenafil citrate (Viagra)

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Abstract

Three types of monocrystalline diamond: natural diamond 1 µm, synthetic diamond 50 µm (synthetic-1), and synthetic diamond 1 µm (synthetic-2) were used for the design of diamond paste electrodes for the determination of sildenafil citrate (Viagra) using square wave voltammetry. The linear concentration ranges recorded for sildenafil citrate when natural diamond, synthetic-1, and synthetic-2 based electrodes were used were between 10−12 and 10−8, 10−12 and 10−9, and 10−11 and 10−9 mol/L, respectively. Low detection limits which lie between 0.1 and 1 pmol/L proves the sensitivity of the electrodes. It was found that sildenafil citrate yielded a peak at about +0.175 ± 0.025 V (versus Ag/AgCl) for all the electrodes. Sildenafil citrate was determined with high reliability from its pharmaceutical formulation.

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Authors and Affiliations

  1. Laboratory of Electrochemistry and PATLAB Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Street, 060021, Bucharest, Romania

    Raluca-Ioana Stefan-van Staden & Jacobus F. van Staden

  2. Pharmaceutical and Medicinal Chemistry Department, The Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, 12311, Egypt

    Hassan Y. Aboul-Enein

Authors
  1. Raluca-Ioana Stefan-van Staden
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  2. Jacobus F. van Staden
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  3. Hassan Y. Aboul-Enein
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Correspondence to Raluca-Ioana Stefan-van Staden.

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Stefan-van Staden, RI., van Staden, J.F. & Aboul-Enein, H.Y. Diamond paste-based electrodes for the determination of sildenafil citrate (Viagra). J Solid State Electrochem 14, 997–1000 (2010). https://doi.org/10.1007/s10008-009-0901-7

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  • DOI: https://doi.org/10.1007/s10008-009-0901-7

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