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Diagnostic and prognostic value of miRNAs on salivary gland tumors: a systematic review and meta-analysis

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Abstract

Purpose

Different levels of miRNA expression have been described in salivary gland tumors as a potential diagnostic marker and predictor of survival. We systematically reviewed the literature to assess the diagnostic and prognostic value of miRNAs on salivary gland tumors.

Methods

An electronic search was conducted in PubMed, Scopus, Embase, Cochrane, and Web of Science databases. In the meta-analysis, we assumed random-effects model with adjusted hazard ratio (HR) and 95% confidence intervals (95% CI). For prognostic studies, the risk of bias was assessed by Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) and Quality Assessment Tool for Diagnostic Accuracy Studies-2 (QUADAS-2) was utilized for diagnostic studies.

Results

Gathered data from 1.131 patients in seven studies demonstrated that different levels of miRNA expression presented diagnostic and prognostic in SGTs. The meta-analysis showed that altered miRNA expression were associated with shortened survival (HR, 2.35, 95% CI, 1.77–3.10, P < .00001). For diagnostic meta-analysis, the overall pooled results for specificity and sensibility were 0.87–0.97 (95% CI, 0.72–1) and 0.68–0.91 (95% CI, 0.51–0.96), respectively.

Conclusion

MicroRNAs may be useful in prognostication of patients with SGTs; however, the diagnostic value of miRNAs in SGTs is still limited.

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Acknowledgements

ESS was supported by the São Paulo Research Foundation (FAPESP) under the grant 2018/19922-9. AGCN is supported by the São Paulo ResearchFoundation (FAPESP) under the grant FAPESP 2019/09692-9. JFS is supported by the São Paulo Research Foundation (FAPESP) under the grant FAPESP2019/09419-0. RALS was supported by the São Paulo Research Foundation (FAPESP) under the grant 2019/06809-2. Adriana Franco Paes Leme is a researcher fellow funded by the Brazilian NationalCouncil for Scientific and Technological Development (CNPq).

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Authors and Affiliations

  1. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil

    Erison Santana Dos Santos, Ana Gabriela Costa Normando, João Figueira Scarini, Lívia Ramalho Crescencio & Reydson Alcides de Lima-Souza

  2. Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

    Fernanda Viviane Mariano

  3. Brazilian Bioscience National Laboratory, The Brazilian Center for Research in Energy and Materials, Campina, São Paulo, Brazil

    Adriana Franco Paes Leme

Authors
  1. Erison Santana Dos Santos
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  2. Ana Gabriela Costa Normando
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  3. João Figueira Scarini
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  4. Lívia Ramalho Crescencio
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  5. Reydson Alcides de Lima-Souza
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  6. Fernanda Viviane Mariano
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  7. Adriana Franco Paes Leme
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Contributions

ESS contributed to conception, design, data acquisition and interpretation, quality control of data and algorithms, drafted, statistical analysis, and critically revised the manuscript. AGCN, JFS, LCR, RALS, FVM, and AFPL contributed to data acquisition and interpretation, statistical analysis, manuscript editing and critically revised the manuscript. FVM and AFPL are supervisors of this work. All authors gave their final approval and agreed to be accountable for all aspects of the work.

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Correspondence to Erison Santana Dos Santos.

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Dos Santos, E.S., Normando, A.G.C., Scarini, J.F. et al. Diagnostic and prognostic value of miRNAs on salivary gland tumors: a systematic review and meta-analysis. Oral Maxillofac Surg 25, 445–456 (2021). https://doi.org/10.1007/s10006-021-00952-0

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