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Usefulness of platelet-rich fibrin as a hemostatic agent after dental extractions in patients receiving anticoagulant therapy with factor Xa inhibitors: a case series

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Abstract

Purpose

To evaluate the clinical outcomes of platelet-rich fibrin (PRF) application for hemostasis after dental extraction in patients receiving anticoagulant therapy with factor Xa inhibitors.

Methods

In total, 25 patients receiving anticoagulant therapy with rivaroxaban or apixaban who required routine dental extraction were evaluated. In all patients, PRF was used for hemostasis in addition to adapting sutures. Bleeding was subjectively assessed using a sterilize gauze pad at 24, 48, and 72 h after the procedure.

Results

All invited participants (n = 25) consented to participate. The PRF clots successfully arrested bleeding after extraction in all patients, with no complications at any time point after the procedure. Favorable soft tissue healing was observed during suture removal at 10 days after the procedure in all patients, with no signs of infection or late healing.

Conclusions

The results of this case series indicate that PRF is a promising natural hemostatic agent for the management of bleeding after dental extraction in patients receiving factor Xa inhibitor therapy. Further controlled clinical studies with larger patient samples are necessary to clarify the findings of this case series.

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Authors and Affiliations

  1. Department of Molecular and Cell Biology, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

    Carlos Fernando de Almeida Barros Mourão & Gutemberg Gomes Alves

  2. Department of Oral Surgery, Dentistry School, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

    Carlos Fernando de Almeida Barros Mourão, Rafael Coutinho de Mello Machado & Mônica Diuana Calasans-Maia

  3. Department of Periodontology, University of Bern, Bern, Switzerland

    Richard J Miron

  4. Department of Maxillofacial, Clinic for Maxillofacial and Plastic Surgery, Johann Wolfgang Goethe University, Frankfurt Am Main, Germany

    Shahram Ghanaati

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  1. Carlos Fernando de Almeida Barros Mourão
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  5. Gutemberg Gomes Alves
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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de Almeida Barros Mourão, C., Miron, R.J., de Mello Machado, R.C. et al. Usefulness of platelet-rich fibrin as a hemostatic agent after dental extractions in patients receiving anticoagulant therapy with factor Xa inhibitors: a case series. Oral Maxillofac Surg 23, 381–386 (2019). https://doi.org/10.1007/s10006-019-00769-y

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  • DOI: https://doi.org/10.1007/s10006-019-00769-y

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