Abstract
Introduction
Thrombosis of vascular anastomosis in the field of reconstructive microsurgery is a clinical problem of extraordinary importance for the devastating consequences for affected patients. Sildenafil has been shown to be relaxing vascular action on the peripheral vascular system in vivo and have an ability to reduce platelet aggregation. There is no study up to date on the effect of sildenafil on microvascular anastomosis, neither experimental studies nor clinical settings.
Material and methods
A purposeful thrombotic back-wall stitch was performed in the groin flap pedicle to obtain an anastomosis with thrombotic potential where the drug effect was studied.
Results
Data in the experimental group treated with papaverine or sildenafil indicate a considerable decrease in the percentage of necrotic flaps (20 % necrotic flaps in papaverine group versus 30 % necrotic flaps in sildenafil group) in comparison with control group (60 % necrotic flaps). In papaverine group, in 100 % cases, flap necrosis was established in the first 24 h, but in sildenafil group, 66 % flap necrosis was established between the second and the seventh postoperative days.
Conclusion
The study did not demonstrate significant differences between the groups, but it does suggest a benefit in applying papaverine and sildenafil in the anastomosis with already thrombogenetic disease, compared to the nonapplication of antithrombotic drugs. The establishment of thrombosis in the necrotic flaps in the group treated with sildenafil was later than in the group treated with papaverine, with a statistical trend but without becoming significant.
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Acknowledgments
Author L. Pingarrón-Martin would like to thank Carlota Largo Aramburu, veterinarian of Department of Experimental Surgery Department of La Paz University Hospital, for the logistical support in carrying out this thesis, for teaching her the importance of animal welfare in experimental surgery, and for the wide availability. As well as to the Department of Oral and Maxillofacial Surgery of La Paz University Hospital and Shanghai Ninth People Hospital, which have contributed to her training as a surgeon and have stimulated her in the field of research and in completing her education abroad.
Financial disclosure
Sildenafil citrate powder has been facilitated by pharmaceutical company Pfizer.
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Pingarrón-Martín, L., Arias-Gallo, L.J. Sildenafil effect on prevention of thrombosis after microsurgical anastomosis: experimental rat model of thrombotic suture. Oral Maxillofac Surg 18, 53–58 (2014). https://doi.org/10.1007/s10006-012-0387-9
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DOI: https://doi.org/10.1007/s10006-012-0387-9