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Comparison of clonidine and midazolam as anxiolytic premedication before wisdom tooth surgery: a randomized, double-blind, crossover pilot study

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Abstract

Purpose

Anxiolytic and possible side effects of clonidine 150 μg compared to midazolam 7.5 mg for premedication in surgical wisdom tooth extraction were evaluated.

Methods

In a prospective, randomized, double-blind crossover trial, ten patients undergoing bilateral wisdom tooth surgery received clonidine or midazolam orally 1 h before the treatment. Patients receiving midazolam for the first surgery received clonidine at the second surgery and vice versa. The anxiolytic efficacy was evaluated with a visual analogue scale (VAS) upon admission and 30, 50 and 60 min after administration of the medication. Patient satisfaction was recorded on a VAS after surgery and 7 days postoperatively.

Results

As soon as 30 min after administration of midazolam (p < 0.03) and clonidine (p < 0.02), an anxiolytic effect was recorded. Both medications did not differ in patient satisfaction.

Conclusion

Oral administration of clonidine 150 μg and midazolam 7.5 mg were rated as medications with equal anxiolytic effects before wisdom tooth surgery under local anesthesia.

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References

  1. Donaldson M, Gizzarelli G, Chanpong B (2007) Oral sedation. A primer on anxiolysis for the adult patient. Anesth Prog 54(3):118–129

    Article  PubMed  Google Scholar 

  2. Gross JB, Bailey PL, Connis RT, Coté CJ, Davis FG, Epstein BS, Gilbertson L, Nickinovich DG, Zerwas JM, Zuccaro G (2002) Practice guidelines for sedation and analgesia by non-anesthesiologists: an update report by the American Society of Anesthesiologists task force on sedation and analgesia by non-anesthesiologists. Anesthesiology 96:1004–10017

    Article  Google Scholar 

  3. Beer GM, Spicher I, Seifert B, Emanuel B, Kompatscher P, Meyer VE (2001) Oral premedication for operations on the face under local anesthesia: a placebo-controlled double-blind trial. Plast Reconstr Surg 108:637–643

    Article  PubMed  CAS  Google Scholar 

  4. Murai T (1995) Effects of clonidine on intravenous sedation with midazolam. Anesth Prog 42:135–138

    PubMed  CAS  Google Scholar 

  5. Fanini D, Poglio M, Marci MC, Iovinelli G, Antenucci F (1998) La premedicazione orale con clonidina come alternative nella pratica odontoiatrica. Minerva Stomatol 47:453–464

    PubMed  CAS  Google Scholar 

  6. Eberhart LH, Novatchkov N, Schricker T, Georgieff M, Baur CP (2000) Clonidin im Vergleich zu Midazolam zur intravenösen Prämedikation vor ambulanten Eingriffen. Anasthesiol Intensivmed Notfallmed Schmerzther 35:388–393

    Article  PubMed  CAS  Google Scholar 

  7. Frank T, Thieme V, Radow L (2000) Prämedikation im Rahmen einer TIVA bei kieferchirurgischen Operationen—Vergleich der perioperativen Verläufe nach Clonidin versus Midazolam. Anästhesiol Intensivmed Notfallmed Schmerzther 35:428–434

    Article  PubMed  CAS  Google Scholar 

  8. Altman DG (1991) Practical statistics for medical research. Chapman & Hall, London

    Google Scholar 

  9. Berendes E, Scherer R, Rotthove K, Prien T (1996) Anxiolyse, Sedierung und Stressreduktion nach oraler Prämedikation mit Midazolam bei Erwachsenen. Ein Vergleich mit Dikaliumclorazepat bzw. Plazebo Anaesthesist 45:506–511

    Article  CAS  Google Scholar 

  10. Zalunardo MP, Ivleva-Sauerborn A, Seifert B, Spahn DR (2010) Quality of premedication and patient satisfaction after premedication with midazolam, clonidine or placebo: randomized double-blind study with age-adjusted dosage. Anaesthesist 59(5):410–418

    Article  PubMed  CAS  Google Scholar 

  11. Paris A, Kaufmann M, Tonner PH, Renz P, Lemke T, Ledowski T, Scholz J, Bein B (2009) Effects of clonidine and midazolam premedication on bispectral index and recovery after elective surgery. Eur J Anaesthesiol 26(7):603–610

    Article  PubMed  CAS  Google Scholar 

  12. Mutzbauer TS, Obwegeser JA, Grätz KW (2005) Clonidine in oral medicine. Literature review and our experience. Schweiz Monatsschr Zahnmed 115(3):214–218

    PubMed  Google Scholar 

  13. Broscheit J, Kranke P (2008) Prämedikation—Charakteristika und Auswahl der Substanzen. Anästhesiol Intensivmed Notfallmed Schmerzther 2:134–142

    Article  Google Scholar 

  14. Kindler CH, Harms C, Amsler F, Ihde-Scholl T, Scheidegger D (2000) The visual analog scale allows effective measurement of preoperative anxiety and detection of patients’ anesthetic concerns. Anesth Analg 90(3):706–712

    Article  PubMed  CAS  Google Scholar 

  15. Wilson KE, Girdler NM, Welbury RR (2006) A comparison of oral midazolam and nitrous oxide sedation for dental extraction in children. Anaesthesia 61:1138–1144

    Article  PubMed  CAS  Google Scholar 

  16. Wilson KE, Welbury RR, Girdler NM (2002) A randomized, controlled, crossover trial of oral midazolam and nitrous oxide for paediatric dental sedation. Anaesthesia 57:860–867

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Craniomaxillofacial and Oral Surgery, University Hospital Zurich, Frauenklinikstr. 24, 8091, Zurich, Switzerland

    Franziska R. Studer & Klaus W. Grätz

  2. Maxillofacial Surgery and Dental Anesthesiology, Tiefenhoefe 11, CH-8001, Zurich, Switzerland

    Till S. Mutzbauer

Authors
  1. Franziska R. Studer
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  2. Klaus W. Grätz
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  3. Till S. Mutzbauer
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Correspondence to Till S. Mutzbauer.

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Studer, F.R., Grätz, K.W. & Mutzbauer, T.S. Comparison of clonidine and midazolam as anxiolytic premedication before wisdom tooth surgery: a randomized, double-blind, crossover pilot study. Oral Maxillofac Surg 16, 341–347 (2012). https://doi.org/10.1007/s10006-012-0319-8

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  • DOI: https://doi.org/10.1007/s10006-012-0319-8

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