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Isotretinoin effect on alveolar repair after exodontia—a study in rats

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Abstract

Objectives

To evaluate isotretinoin effect on alveolar repair after tooth extraction of maxillary incisor and serum calcium levels in rats.

Study design

Wistar rats (60-day-old) were assigned to control (CG, n = 12) and experimental (EG, n = 20) groups. EG received daily isotretinoin (7.5 mg/kg) for 30 days before surgery and until euthanasia, 7, 21, 28, or 90 days after tooth extraction. Blood was collected in the EG to analyze serum calcium levels before isotretinoin administration and at euthanasia. Right hemimaxillae underwent histological examination, and the slides were stained with HE and analyzed by descriptive light microscopy.

Results

There was acceleration in the process of alveolar repair in the EG at all time points when compared to controls. Serum calcium levels showed a statistically significant decrease between first and second blood collection at days 21, 28, and 90.

Conclusions

Daily isotretinoin in a dose corresponding to the treatment of cystic acne accelerated alveolar repair.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthodontics, School of Dentistry, Universidade Federal de Pelotas (UFPEL), Rua Gonçalves Chaves, 3.657/401 B, Pelotas, Rio Grande do Sul, Brazil, CEP 96015-560-Bairro: Centro

    Roberta Dalmolin Bergoli & Otacilio Luiz Chagas Junior

  2. Oral and Maxillofacial Surgery Post-Graduate Program, School of Dentistry, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil

    Carlos Eduardo Chrzanowski Pereira de Souza & Beatriz Farias Vogt

  3. Dentistry Department, Fundação para Reabilitação das Deformidades Cranio Faciais (FUNDEF), Lajeado, RS, Brazil

    Henrique Telles Ramos de Oliveira

  4. Discipline of Oral Pathology, School of Dentistry, Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil

    Adriana Etges

  5. School of Dentistry, Universidade Federal do Espírito Santo (UFES), Vitoria, ES, Brazil

    Daniela Nascimento Silva

Authors
  1. Roberta Dalmolin Bergoli
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  2. Otacilio Luiz Chagas Junior
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  3. Carlos Eduardo Chrzanowski Pereira de Souza
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  4. Beatriz Farias Vogt
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  5. Henrique Telles Ramos de Oliveira
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  6. Adriana Etges
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Correspondence to Roberta Dalmolin Bergoli.

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Bergoli, R.D., Chagas Junior, O.L., de Souza, C.E.C.P. et al. Isotretinoin effect on alveolar repair after exodontia—a study in rats. Oral Maxillofac Surg 15, 85–92 (2011). https://doi.org/10.1007/s10006-010-0235-8

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  • DOI: https://doi.org/10.1007/s10006-010-0235-8

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