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DNA-Ploidie und proliferative Aktivität bei Speicheldrüsentumoren

DNA ploidy and proliferative activity in salivary gland tumours

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Zusammenfassung

Mithilfe hoch-auflösender DNA-Durchflusszytophotometrie wurden DNA-Ploidie und S-Phasenfraktion (SPF) bei 279 Speicheldrüsentumoren bestimmt. Alle 229 benignen Neoplasien waren diploid; 12 von 50 malignen Tumoren wiesen Zellpopulationen mit aneuploidem DNA-Gehalt auf. Die SPF-Werte der diploiden Malignome waren signifikant höher als bei pleomorphen Adenomen, unterschieden sich jedoch nicht von denen der Zystadenolymphome (Warthin-Tumoren). Während Aneuploidie ein Malignitätsmerkmal darstellt, ist der SPF-Wert für die Dignitätsdiagnostik bei Speicheldrüsentumoren nur von eingeschränktem Nutzen.

Abstract

DNA ploidy and S-Phase fraction (SPF) of 279 salivary gland tumours were analysed using high-resolution DNA flow cytometry. All 229 benign neoplasms were diploid while 12 of 50 malignant tumours showed cell populations with aneuploid DNA content. The SPF values of diploid malignancies were significantly higher if compared with pleomorphic adenomas but did not differ from that of the zystadenolymphoma (Warthin tumour) group. While aneuploidy represents a distinct indicator of malignancy SPF values are of minor relevance for dignity assessment in salivary gland tumours.

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Anmerkung

Weitere Informationen zur Durchflusszytophotometrie und DNA-Ploidie bei Kopf-Hals-Tumoren unter http://www. aneuploidy.info.

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Authors and Affiliations

  1. Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany

    Oliver Driemel

  2. Abteilung Pathologie, Bundeswehrkrankenhaus Ulm, Oberer Eselsberg 40, 89081, Ulm, Germany

    Klaus Kraft

  3. Abteilung Pathologie, Universität Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany

    Jörg Hemmer

  4. Department of Oral Pathology, University of Pretoria, 0002, Pretoria, South Africa

    Jörg Hemmer

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  1. Oliver Driemel
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  2. Klaus Kraft
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  3. Jörg Hemmer
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Correspondence to Jörg Hemmer.

Additional information

Vortrag gehalten bei der 36. Jahrestagung des Deutsch-Österreichisch-Schweizerischen Arbeitskreises für Tumoren im Kiefer- und Gesichtsbereich (DÖSAK) innerhalb der Deutschen Gesellschaft für Mund-, Kiefer- und Gesichtschirurgie in Bochum, 14.–15.November 2005.

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Driemel, O., Kraft, K. & Hemmer, J. DNA-Ploidie und proliferative Aktivität bei Speicheldrüsentumoren. Mund Kiefer GesichtsChir 11, 139–144 (2007). https://doi.org/10.1007/s10006-007-0060-x

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